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GGT1(1-380) [plasma membrane]
Stable Identifier
R-HSA-1247889
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GGT1 heavy chain, GGT1, GGT1hc, Gamma-glutamyltranspeptidase 1, GGT1_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
LTC4-CYSLTR mediated IL4 production (Homo sapiens)
GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Homo sapiens)
GGT1, 5 dimers [plasma membrane] (Homo sapiens)
GGT1 dimer [plasma membrane] (Homo sapiens)
GGT1(1-380) [plasma membrane] (Homo sapiens)
LTC4 binds CyslTR1,2 (Homo sapiens)
GGT1 dimer [plasma membrane] (Homo sapiens)
GGT1(1-380) [plasma membrane] (Homo sapiens)
Drug ADME (Homo sapiens)
Paracetamol ADME (Homo sapiens)
GGT dimers hydrolyse APAP-SG (Homo sapiens)
GGT dimers [plasma membrane] (Homo sapiens)
GGT1 dimer [plasma membrane] (Homo sapiens)
GGT1(1-380) [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Aflatoxin activation and detoxification (Homo sapiens)
GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG (Homo sapiens)
GGT dimers [plasma membrane] (Homo sapiens)
GGT1 dimer [plasma membrane] (Homo sapiens)
GGT1(1-380) [plasma membrane] (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Glutathione conjugation (Homo sapiens)
Glutathione synthesis and recycling (Homo sapiens)
GGT dimers hydrolyse GSH (Homo sapiens)
GGT dimers [plasma membrane] (Homo sapiens)
GGT1 dimer [plasma membrane] (Homo sapiens)
GGT1(1-380) [plasma membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of Leukotrienes (LT) and Eoxins (EX) (Homo sapiens)
GGT1, 5 dimers hydrolyse LTC4 to LTD4 (Homo sapiens)
GGT1, 5 dimers [plasma membrane] (Homo sapiens)
GGT1 dimer [plasma membrane] (Homo sapiens)
GGT1(1-380) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19440 GGT1
Gene Names
GGT1, GGT
Chain
chain:1-380, chain:381-569
Reference Genes
BioGPS Gene:2678 P194403
COSMIC (genes):GGT1 GGT1
CTD Gene:2678 P194403
dbSNP Gene:2678 GGT1
ENSEMBL:ENSG00000100031 GGT1
HGNC:4250 P194403
KEGG:hsa:2678 P194403
Monarch:2678 P194403
NCBI Gene:2678 P194403
OMIM:612346 P194403
UCSC:P19440 P194403
Reference Transcript
RefSeq:NM_013421.3 P194403
RefSeq:NM_013430.3 P194403
RefSeq:NM_001288833.2 P194403
Participates
as a component of
GGT1 dimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
GGT1(381-569) [plasma membrane]
GGT1(381-569) D423A [plasma membrane]
GGT1(1-380) R107Q [plasma membrane]
GGT1(381-569) S451A [plasma membrane]
GGT1(1-380) R107H [plasma membrane]
GGT1(381-569) D423E [plasma membrane]
GGT1(381-569) S452A [plasma membrane]
Inferred To
Dmel\CG4829 [plasma membrane]
(Drosophila melanogaster)
ggt2 [plasma membrane]
(Schizosaccharomyces pombe)
GGT1(1-380) [plasma membrane]
(Caenorhabditis elegans)
GGT1(1-380) [plasma membrane]
(Canis familiaris)
GGT2 [plasma membrane]
(Gallus gallus)
Ggt1 [plasma membrane]
(Mus musculus)
Ggt1 [plasma membrane]
(Rattus norvegicus)
Homologues of GGT1(1-380) [plasma membrane]
(Danio rerio)
ggt1b [plasma membrane]
(Danio rerio)
ECM38 [plasma membrane]
(Saccharomyces cerevisiae)
ggt1l2.2 [plasma membrane]
(Danio rerio)
GGT1 [plasma membrane]
(Bos taurus)
GGT1 [plasma membrane]
(Sus scrofa)
Ghost homologue of GGT1(1-380) [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_038347.2
,
NP_001275762.1
,
NP_038265.2
OpenTargets
ENSG00000286070
,
ENSG00000100031
ENSEMBL
ENST00000403838
,
ENSP00000384381
,
ENSP00000383231
,
ENSP00000387499
,
ENSP00000383232
,
ENST00000425895
,
ENST00000401885
,
ENST00000400380
,
ENSG00000100031
,
ENST00000400382
,
ENST00000404532
,
ENSP00000385445
,
ENSP00000384820
HPA
ENSG00000100031-GGT1
GeneCards
GGT1
ZINC - Substances
GGT1_HUMAN
ZINC target
P19440
PRO
P19440
Pharos - Targets
P19440
Orphanet
GGT1
HMDB Protein
HMDBP00730
PDB
4ZCG
,
4ZC6
,
4GDX
,
4Z9O
,
4ZBK
,
5V4Q
,
4GG2
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