Reactome | Hemoglobin A binds O2, releasing H+ and CO2

Hemoglobin A binds O2, releasing H+ and CO2

Stable Identifier

R-HSA-1247668

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Hemoglobin A binds oxygen and releases protons and carbon dioxide, Haldane Effect

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Hemoglobin A binds O2, releasing H+ and CO2

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The binding of oxygen (O2) to hemoglobin (HbA) decreases the affinity of HbA for protons (H+) bound at histidine residues and carbon dioxide (CO2) bound chemically as a carbamate at the N-terminus of the HbA (Ferguson and Roughton 1934, Kernohan & Roughton 1968, Klocke 1973, Morrow et al. 1973, Morrow et al. 1976, Tazawa et al. 1983, Kraan & Rispens 1985, Doyle et al. 1987, Mertzlufft & Brandt 1989, Kalhoff et al.1994, Dash & Bassingthwaighte 2010, reviewed in Jensen 2004). This property of HbA is known as the Haldane Effect and facilitates the exchange of CO2 for O2 in the lungs.

Literature References

PubMed ID	Title	Journal	Year
7541176	The Haldane effect under different acid-base conditions in premature and adult humans Kalhoff, H, Werkmeister, F, Kiwull-Schöne, H, Diekmann, L, Manz, F, Kiwull, P	Adv Exp Med Biol	1994
4514311	Interaction of 13 CO 2 and bicarbonate with human hemoglobin preparations Morrow, JS, Keim, P, Visscher, RB, Marshall, RC, Gurd, FR	Proc Natl Acad Sci U S A	1973
16994616	The chemical relationships and physiological importance of carbamino compounds of CO(2) with haemoglobin Ferguson, JK, Roughton, FJ	J Physiol	1934
4975618	Thermal studies of the rates of the reactions of carbon dioxide in concentrated haemoglobin solutions and in red blood cells. A. The reactions catalysed by carbonic anhydrase. B. The carbamino reactions of oxygenated and deoxygenated haemoglobin Kernohan, JC, Roughton, FJ	J Physiol	1968
3119859	Carbon dioxide and oxygen linkage in human hemoglobin tetramers Doyle, ML, Di Cera, E, Robert, CH, Gill, SJ	J Mol Biol	1987
20162361	Erratum to: Blood HbO2 and HbCO2 dissociation curves at varied O2, CO2, pH, 2,3-DPG and temperature levels Dash, RK, Bassingthwaighte, JB	Ann Biomed Eng	2010
1395	Carbon 13 resonances of 13CO2 carbamino adducts of alpha and beta chains in human adult hemoglobin Morrow, JS, Matthew, JB, Wittebort, RJ, Gurd, FR	J Biol Chem	1976
3938604	Contribution of the Haldane effect to the increase in arterial carbon dioxide tension in hypoxaemic subjects treated with oxygen Kraan, J, Rispens, P	Adv Exp Med Biol	1985
2506737	Hyperoxic intubation apnoea: an in vivo model for the proof of the Christiansen-Douglas-Haldane effect Mertzlufft, F, Brandt, L	Adv Exp Med Biol	1989
4203704	Mechanism and kinetics of the Haldane effect in human erythrocytes Klocke, RA	J Appl Physiol	1973
6417382	Quantitative analyses of the CO2 dissociation curve of oxygenated blood and the Haldane effect in human blood Tazawa, H, Mochizuki, M, Tamura, M, Kagawa, T	Jpn J Physiol	1983