Acireductone is oxidized to MOB

Stable Identifier
R-HSA-1237119
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Acireducone (1,2-Dihydroxy-3-oxo-5'-methylthiopentene) is oxidized using acireductone dioxygenase and dioxygen. There are two reactions possible, dependent on the metal cofactor: the alternative product 3-methylthiopropionate using nickel was confirmed in Klebsiella. In eukaryotes using iron(II) the result is 4-methylthio-2-oxobutanoate (MOB). (Ju et al, 2006)

Literature References
PubMed ID Title Journal Year
17786183 Expression and function of the human androgen-responsive gene ADI1 in prostate cancer

Oram, SW, Ai, J, Pagani, GM, Hitchens, MR, Stern, JA, Eggener, S, Pins, M, Xiao, W, Cai, X, Haleem, R, Jiang, F, Pochapsky, TC, Hedstrom, L, Wang, Z

Neoplasia 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acireductone dioxygenase [iron(II)-requiring] activity of ARD:Fe++ [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created