Acireductone is oxidized to MOB

Stable Identifier
R-HSA-1237119
Type
Reaction
Species
Homo sapiens
Compartment
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Acireducone (1,2-Dihydroxy-3-oxo-5'-methylthiopentene) is oxidized using acireductone dioxygenase and dioxygen. There are two reactions possible, dependent on the metal cofactor: the alternative product 3-methylthiopropionate using nickel was confirmed in Klebsiella. In eukaryotes using iron(II) the result is 4-methylthio-2-oxobutanoate (MOB). (Ju et al, 2006)

Literature References
PubMed ID Title Journal Year
17786183 Expression and function of the human androgen-responsive gene ADI1 in prostate cancer

Hedstrom, L, Cai, X, Haleem, R, Xiao, W, Pagani, GM, Jiang, F, Pochapsky, TC, Wang, Z, Stern, JA, Eggener, S, Hitchens, MR, Pins, M, Ai, J, Oram, SW

Neoplasia 2007
Participants
Participates
Catalyst Activity

acireductone dioxygenase [iron(II)-requiring] activity of ARD:Fe++ [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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