Reactome | Acireductone is oxidized to MOB

Acireductone is oxidized to MOB

Stable Identifier

R-HSA-1237119

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 => 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)

ReviewStatus

5/5

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Acireducone (1,2-Dihydroxy-3-oxo-5'-methylthiopentene) is oxidized using acireductone dioxygenase and dioxygen. There are two reactions possible, dependent on the metal cofactor: the alternative product 3-methylthiopropionate using nickel was confirmed in Klebsiella. In eukaryotes using iron(II) the result is 4-methylthio-2-oxobutanoate (MOB). (Ju et al, 2006)

Literature References

PubMed ID	Title	Journal	Year
17786183	Expression and function of the human androgen-responsive gene ADI1 in prostate cancer Oram, SW, Ai, J, Pagani, GM, Hitchens, MR, Stern, JA, Eggener, S, Pins, M, Xiao, W, Cai, X, Haleem, R, Jiang, F, Pochapsky, TC, Hedstrom, L, Wang, Z	Neoplasia	2007