Transamination of MOB to methionine

Stable Identifier
R-HSA-1237102
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid => a 2-oxocarboxylate + L-methionine
ReviewStatus
5/5
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Transamination of MOB to methionine
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In the last step MOB is transaminated to methionine. The reaction was confirmed in yeast, where several transaminases catalyze it, which appears to be also the case in rat. The human enzymes involved are unknown but homology to the respective enzyme in the parasite Crithidia fasciculata supports the conclusion that human GOT is probably one of the involved transaminases (Berger et al, 2001).
Literature References
PubMed ID Title Journal Year
11443076 Methionine regeneration and aspartate aminotransferase in parasitic protozoa

Berger, LC, Wilson, J, Wood, P, Berger, BJ

J Bacteriol 2001
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
L-methionine salvage from methylthioadenosine (0019509)
Catalyst Activity

transaminase activity of PXLP-K259-GOT1 dimer [cytosol]

Physical Entity
PXLP-K259-GOT1 dimer [cytosol] (Homo sapiens)
Activity
transaminase activity (GO:0008483)
Inferred From
Transamination of MOB to methionine (Crithidia fasciculata)
Cross References
RHEA
Authored
Stephan, R  (2010-10-24)
Reviewed
D'Eustachio, P  (2011-05-23)
Created
Jassal, B  (2011-03-30)
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