Reactome | MTAP [cytosol]

MTAP [cytosol]

Stable Identifier

R-HSA-1237091

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of S-methyl-5'-thioadenosine phosphorylase (Homo sapiens)
        
        MTAP [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13126 MTAP

Gene Names

MTAP, MSAP

Chain

chain:1-283

Reference Genes

BioGPS Gene:4507 MTAP

COSMIC (genes):MTAP MTAP

CTD Gene:4507 MTAP

dbSNP Gene:4507 MTAP

ENSEMBL:ENSG00000099810 MTAP

HGNC:7413 MTAP

KEGG:hsa:4507 MTAP

Monarch:4507 MTAP

NCBI Entrez Gene:4507 MTAP

OMIM:156540 MTAP

UCSC:Q13126 MTAP

Reference Transcript

Other Identifiers

11726115_at

11726116_at

11726117_a_at

11748840_a_at

11751853_s_at

17083975

17083988

204956_PM_at

204956_at

211363_PM_s_at

211363_s_at

216685_PM_s_at

216685_s_at

231984_PM_at

231984_at

3164915

3164916

3164917

3164920

3164923

3164924

3164926

3164927

3164928

3164929

3164932

3164936

3164937

3164938

3164939

3164940

3164943

3164946

3164947

3164948

3164949

3164950

3164951

3164952

3164953

3164954

3164955

3164956

3164957

3164958

3164959

3164975

3164976

3164977

3164978

3164979

38150_at

41942_at

4507

76183_at

8154635

A_14_P101143

A_19_P00315788

A_19_P00806737

A_24_P196519

A_24_P297888

A_24_P51118

A_33_P3329108

GE62492

GO:0003824

GO:0004645

GO:0004731

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006139

GO:0006166

GO:0006520

GO:0006790

GO:0009116

GO:0016740

GO:0016757

GO:0016763

GO:0017061

GO:0019509

GO:0032259

GO:0033574

GO:0055086

GO:0070062

GO:1901135

HMNXSV003023741

Hs.118190.0.S1_3p_at

Hs.152817.1.S1_3p_a_at

Hs.152817.1.S1_3p_x_at

ILMN_1753639

TC09000105.hg

TC09001845.hg

TC09002880.hg

U22233_at

Participates

as an output of

Expression of S-methyl-5'-thioadenosine phosphorylase (Homo sapiens)

as a component of

MTAP trimer [cytosol] (Homo sapiens)

Inferred To

MTAP [cytosol] (Bos taurus)

MTAP [cytosol] (Caenorhabditis elegans)

MTAP [cytosol] (Canis familiaris)

MTAP [cytosol] (Danio rerio)

MTAP [cytosol] (Drosophila melanogaster)

MTAP [cytosol] (Gallus gallus)

MTAP [cytosol] (Mus musculus)

MTAP [cytosol] (Rattus norvegicus)

MTAP [cytosol] (Saccharomyces cerevisiae)

MTAP [cytosol] (Schizosaccharomyces pombe)

MTAP [cytosol] (Sus scrofa)

MTAP [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001382970.1, NP_001382971.1, NP_001382972.1, NP_002442.2, NP_001382973.1, NP_001382974.1

OpenTargets

ENSG00000099810

ENSEMBL

ENSG00000099810, ENST00000644715, ENSP00000494373, ENSP00000463424, ENST00000580900

ZINC - Substances

MTAP_HUMAN

ZINC target

Q13126

PRO

Q13126

GlyGen

Q13126

PDB

1K27, 6DZ0, 1SD1, 5TC5, 3OZE, 6DZ3, 6DZ2, 5TC7, 6DYZ, 5TC6, 3OZD, 5TC8, 1SD2, 3OZC, 5EUB, 1CG6, 3LN5, 1CB0

HPA

ENSG00000099810-MTAP

GeneCards

MTAP

Pharos - Targets

Q13126

Orphanet

MTAP

ZINC - Predictions - Purchasable

MTAP_HUMAN

HMDB Protein

HMDBP00397

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H3R5 CENPH	2	CENPH [nucleoplasm] (R-HSA-606314) CENPH [cytosol] (R-HSA-375294)	0.556	3
UniProt:Q9P0I2 EMC3	1	EMC3 [endoplasmic reticulum membrane] (R-HSA-9714347)	0.556	3