Reactome | MTAP [cytosol]

MTAP [cytosol]

Stable Identifier

R-HSA-1237091

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of S-methyl-5'-thioadenosine phosphorylase (Homo sapiens)
        
        MTAP [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13126 MTAP

Gene Names

MTAP, MSAP

Chain

chain:1-283

Reference Genes

BioGPS Gene:4507 MTAP

COSMIC (genes):MTAP MTAP

CTD Gene:4507 MTAP

dbSNP Gene:4507 MTAP

ENSEMBL:ENSG00000099810 MTAP

ENSEMBL_homo_sapiens_GENE:ENSG00000099810.21 MTAP

HGNC:7413 MTAP

KEGG Gene (Homo sapiens):4507 MTAP

Monarch:4507 MTAP

NCBI Gene:4507 MTAP

OMIM:156540 MTAP

UCSC:Q13126 MTAP

Reference Transcript

RefSeq:NM_002451.3 MTAP

Other Identifiers

11726115_at

11726116_at

11726117_a_at

11748840_a_at

11751853_s_at

17083975

204956_PM_at

204956_at

211363_PM_s_at

211363_s_at

216685_PM_s_at

216685_s_at

231984_PM_at

231984_at

3164915

3164916

3164926

3164927

3164928

3164932

3164936

3164937

3164940

3164946

3164947

3164948

3164949

3164950

3164951

3164952

3164953

3164954

3164955

3164956

3164957

3164958

3164959

3164976

3164977

3164978

3164979

38150_at

41942_at

4507

76183_at

8154635

A_14_P101143

A_19_P00315788

A_19_P00806737

A_24_P196519

A_24_P297888

A_24_P51118

A_33_P3329108

GE62492

GO:0003824

GO:0004645

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006139

GO:0006166

GO:0006520

GO:0006790

GO:0009116

GO:0016740

GO:0016757

GO:0016763

GO:0017061

GO:0019509

GO:0032259

GO:0033574

GO:0043226

GO:0055086

GO:0070062

GO:1901135

HMNXSV003023741

Hs.118190.0.S1_3p_at

Hs.152817.1.S1_3p_a_at

Hs.152817.1.S1_3p_x_at

ILMN_1753639

TC09001845.hg

TC09002880.hg

U22233_at

Participates

as an output of

Expression of S-methyl-5'-thioadenosine phosphorylase (Homo sapiens)

as a component of

MTAP trimer [cytosol] (Homo sapiens)

Inferred To

MTAP [cytosol] (Bos taurus)

MTAP [cytosol] (Caenorhabditis elegans)

MTAP [cytosol] (Canis familiaris)

MTAP [cytosol] (Danio rerio)

MTAP [cytosol] (Drosophila melanogaster)

MTAP [cytosol] (Gallus gallus)

MTAP [cytosol] (Mus musculus)

MTAP [cytosol] (Rattus norvegicus)

MTAP [cytosol] (Saccharomyces cerevisiae)

MTAP [cytosol] (Schizosaccharomyces pombe)

MTAP [cytosol] (Sus scrofa)

MTAP [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_002442.2

OpenTargets

ENSG00000099810

ZINC - Substances

MTAP_HUMAN

ZINC target

Q13126

PRO

Q13126

PDB

6DZ3, 3OZE, 5EUB, 5TC6, 1K27, 3OZC, 3OZD, 5TC5, 6DZ2, 6DYZ, 5TC8, 1SD1, 1CB0, 1CG6, 1SD2, 6DZ0, 3LN5, 5TC7

GeneCards

Q13126

HPA

ENSG00000099810-MTAP

Ensembl

ENST00000580900, ENSP00000494373, ENST00000644715, ENSP00000463424, ENSG00000099810

Pharos - Targets

Q13126

Orphanet

21091

ZINC - Predictions - Purchasable

MTAP_HUMAN

HMDB Protein

HMDBP00397

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9P0I2 EMC3	1	EMC3 [endoplasmic reticulum membrane] (R-HSA-9714347)	0.556	3
UniProt:Q9H3R5 CENPH	2	CENPH [nucleoplasm] (R-HSA-606314) CENPH [cytosol] (R-HSA-375294)	0.556	3