Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide

Stable Identifier
Reaction [transition]
Homo sapiens
H+ + HCO3- -> H2O + CO2
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Carbonic anhydrase VI (CA6) dehydrates bicarbonate to yield water and carbon dioxide (Thatcher et al. 1998, Nishimori et al. 2007). Depending on the concentrations of reactants the reaction is reversible. CA6 is a major protein of saliva and is also known as gustin.

Literature References
PubMed ID Title Journal Year
17499996 Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines

Nishimori, I, Onishi, S, Vullo, D, Innocenti, A, Scozzafava, A, Supuran, CT

Bioorg Med Chem 2007
17228881 Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors

Nishimori, I, Minakuchi, T, Onishi, S, Vullo, D, Scozzafava, A, Supuran, CT

J Med Chem 2007
9784398 Gustin from human parotid saliva is carbonic anhydrase VI

Thatcher, BJ, Doherty, AE, Orvisky, E, Martin, BM, Henkin, RI

Biochem Biophys Res Commun 1998
9336012 Structure and mechanism of carbonic anhydrase

Lindskog, S

Pharmacol Ther 1997
Event Information
Catalyst Activity

carbonate dehydratase activity of CA6:Zinc [extracellular region]

Orthologous Events
Cross References
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