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N-seryl-glycosylphosphatidylinositolethanolamine-CA4 [plasma membrane]
Stable Identifier
R-HSA-1237024
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CA4, Carbonic anhydrase 4, CAH4_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Reversible hydration of carbon dioxide (Homo sapiens)
Carbonic anhydrase dehydrates bicarbonate (plasma membrane) (Homo sapiens)
CA4,9,14,12:Zn2+ [plasma membrane] (Homo sapiens)
CA4:Zn2+ [plasma membrane] (Homo sapiens)
N-seryl-glycosylphosphatidylinositolethanolamine-CA4 [plasma membrane] (Homo sapiens)
Carbonic anhydrase hydrates carbon dioxide (plasma membrane) (Homo sapiens)
CA4,9,14,12:Zn2+ [plasma membrane] (Homo sapiens)
CA4:Zn2+ [plasma membrane] (Homo sapiens)
N-seryl-glycosylphosphatidylinositolethanolamine-CA4 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
O2/CO2 exchange in erythrocytes (Homo sapiens)
Erythrocytes take up carbon dioxide and release oxygen (Homo sapiens)
CA4:Zn2+ hydrates CO2 to HCO3- (Homo sapiens)
CA4:Zn2+ [plasma membrane] (Homo sapiens)
N-seryl-glycosylphosphatidylinositolethanolamine-CA4 [plasma membrane] (Homo sapiens)
Erythrocytes take up oxygen and release carbon dioxide (Homo sapiens)
CA4:Zn2+ dehydrates HCO3- to CO2 (Homo sapiens)
CA4:Zn2+ [plasma membrane] (Homo sapiens)
N-seryl-glycosylphosphatidylinositolethanolamine-CA4 [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
7625839
Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity
Sly, WS
,
Kusumoto, W
,
Okuyama, T
,
Waheed, A
,
Zhu, XL
Arch Biochem Biophys
1995
External Reference Information
External Reference
UniProt:P22748 CA4
Gene Names
CA4
Chain
signal peptide:1-18, chain:19-284, propeptide:285-312
Reference Genes
BioGPS Gene:762 CA4
COSMIC (genes):CA4 CA4
CTD Gene:762 CA4
dbSNP Gene:762 CA4
ENSEMBL:ENSG00000167434 CA4
ENSEMBL_homo_sapiens_GENE:ENSG00000167434.10 CA4
HGNC:1375 CA4
KEGG Gene (Homo sapiens):762 CA4
Monarch:762 CA4
NCBI Gene:762 CA4
OMIM:114760 CA4
UCSC:P22748 CA4
Reference Transcript
RefSeq:NM_000717.4 CA4
RefSeq:XM_017025012.1 CA4
Other Identifiers
11730973_a_at
16836655
206208_3p_at
206208_PM_at
206208_at
206209_PM_s_at
206209_s_at
3729444
3729445
3729453
3729455
3729457
3729458
3729460
3729461
3729464
3729465
3729466
3729467
3729469
40739_at
762
8008900
A_23_P4096
GE58106
GO:0003824
GO:0004089
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005791
GO:0005793
GO:0005794
GO:0005802
GO:0005886
GO:0006730
GO:0008270
GO:0009897
GO:0009986
GO:0015701
GO:0016020
GO:0016324
GO:0016829
GO:0030658
GO:0030667
GO:0031410
GO:0031526
GO:0043226
GO:0046872
GO:0048471
GO:0070062
GO:0098552
HMNXSV003035897
ILMN_1695157
L10955_cds1_s_at
PH_hs_0004987
TC17000736.hg
g9951925_3p_at
g9951925_3p_s_at
Participates
as a component of
CA4:Zn2+ [plasma membrane] (Homo sapiens)
Inferred To
CA4 [plasma membrane]
(Canis familiaris)
CA4 [plasma membrane]
(Gallus gallus)
CA4 [plasma membrane]
(Sus scrofa)
ca4.2 [plasma membrane]
(Xenopus tropicalis)
Homologues of N-seryl-glycosylphosphatidylinositolethanolamine-CA4 [plasma membrane]
(Caenorhabditis elegans)
Homologues of N-seryl-glycosylphosphatidylinositolethanolamine-CA4 [plasma membrane]
(Drosophila melanogaster)
N-seryl-glycosylphosphatidylinositolethanolamine-CA4 [plasma membrane]
(Bos taurus)
N-seryl-glycosylphosphatidylinositolethanolamine-CA4 [plasma membrane]
(Caenorhabditis elegans)
N-seryl-glycosylphosphatidylinositolethanolamine-CA4 [plasma membrane]
(Mus musculus)
N-seryl-glycosylphosphatidylinositolethanolamine-CA4 [plasma membrane]
(Rattus norvegicus)
ca4a [plasma membrane]
(Danio rerio)
CAH2 [plasma membrane]
(Drosophila melanogaster)
CAH9 [plasma membrane]
(Drosophila melanogaster)
Modified Residues
Name
N-seryl-glycosylphosphatidylinositolethanolamine at 284
Coordinate
284
PsiMod Name
N-seryl-glycosylphosphatidylinositolethanolamine [MOD:00171]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to N-seryl-glycosylphosphatidylinositolethanolamine.
Cross References
RefSeq
NP_000708.1
,
XP_016880501.1
ZINC - World Drugs
CAH4_HUMAN
Guide to Pharmacology - Targets
2599
OpenTargets
ENSG00000167434
ZINC - FDA approved
CAH4_HUMAN
ZINC - Substances
CAH4_HUMAN
ZINC - Biogenic
CAH4_HUMAN
ZINC target
P22748
PRO
P22748
PDB
3F7U
,
5IPZ
,
5JNA
,
5JN9
,
5KU6
,
3F7B
,
1ZNC
,
3FW3
,
5JNC
,
5JN8
ZINC - Investigational
CAH4_HUMAN
ZINC - Metabolites
CAH4_HUMAN
IntEnz
4.2.1.1
HPA
ENSG00000167434-CA4
GeneCards
P22748
Ensembl
ENST00000586876
,
ENSG00000167434
,
ENSP00000300900
,
ENST00000300900
,
ENSP00000467465
Pharos - Targets
P22748
ZINC - Predictions - Purchasable
CAH4_HUMAN
Orphanet
15389
HMDB Protein
HMDBP03137
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6R1 SLC4A4
10
SLC4A4 S427L [plasma membrane]
(R-HSA-5656235)
SLC4A4 W516* [plasma membrane]
(R-HSA-5656234)
SLC4A4 T485S [plasma membrane]
(R-HSA-5656220)
SLC4A4 A799V [plasma membrane]
(R-HSA-5656206)
SLC4A4 S982Nfs*4 [plasma membrane]
(R-HSA-5656238)
SLC4A4 R298S [plasma membrane]
(R-HSA-5656208)
SLC4A4 [plasma membrane]
(R-HSA-425545)
SLC4A4 Q29* [plasma membrane]
(R-HSA-5656274)
SLC4A4 R510H [plasma membrane]
(R-HSA-5656210)
SLC4A4 L522P [plasma membrane]
(R-HSA-5656211)
0.463
2
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