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About
What is Reactome ?
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Team
Scientific Advisory Board
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Our Logo
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Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
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ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
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How do I search ?
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CA2 [cytosol]
Stable Identifier
R-HSA-1237012
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Carbonic anhydrase 2, CAH2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Reversible hydration of carbon dioxide (Homo sapiens)
Carbonic anhydrase dehydrates bicarbonate (cytosol) (Homo sapiens)
CA1,2,3,7,13:Zinc [cytosol] (Homo sapiens)
CA2:Zn2+ [cytosol] (Homo sapiens)
CA2 [cytosol] (Homo sapiens)
Carbonic anhydrase hydrates carbon dioxide (cytosol) (Homo sapiens)
CA1,2,3,7,13:Zinc [cytosol] (Homo sapiens)
CA2:Zn2+ [cytosol] (Homo sapiens)
CA2 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
O2/CO2 exchange in erythrocytes (Homo sapiens)
Erythrocytes take up carbon dioxide and release oxygen (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ bind CA inhibitors (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Homo sapiens)
CA2:Zn2+ [cytosol] (Homo sapiens)
CA2 [cytosol] (Homo sapiens)
CA1:Zn2+,CA2:Zn2+:CA inhibitors [cytosol] (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Homo sapiens)
CA2:Zn2+ [cytosol] (Homo sapiens)
CA2 [cytosol] (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ hydrate CO2 to HCO3- (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Homo sapiens)
CA2:Zn2+ [cytosol] (Homo sapiens)
CA2 [cytosol] (Homo sapiens)
Erythrocytes take up oxygen and release carbon dioxide (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ dehydrate HCO3- to CO2 (Homo sapiens)
CA1:Zn2+,CA2:Zn2+ [cytosol] (Homo sapiens)
CA2:Zn2+ [cytosol] (Homo sapiens)
CA2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00918 CA2
Gene Names
CA2
Chain
initiator methionine:, chain:2-260
Reference Genes
BioGPS Gene:760 CA2
COSMIC (genes):CA2 CA2
CTD Gene:760 CA2
dbSNP Gene:760 CA2
ENSEMBL:ENSG00000104267 CA2
ENSEMBL_homo_sapiens_GENE:ENSG00000104267.10 CA2
HGNC:1373 CA2
KEGG Gene (Homo sapiens):760 CA2
Monarch:760 CA2
NCBI Gene:760 CA2
OMIM:611492 CA2
Reference Transcript
RefSeq:NM_000067.2 CA2
Other Identifiers
11733115_a_at
17070456
209301_PM_at
209301_at
3105607
3105608
3105611
3105616
3105617
3105620
3105624
3105627
3105628
3105629
3105630
40095_at
75200_r_at
760
8147132
A_14_P112158
A_23_P8913
GE57471
GO:0002009
GO:0003824
GO:0004064
GO:0004089
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005886
GO:0006730
GO:0008270
GO:0015670
GO:0016020
GO:0016787
GO:0016829
GO:0018820
GO:0023052
GO:0032230
GO:0032849
GO:0038166
GO:0043209
GO:0043226
GO:0044070
GO:0045177
GO:0046872
GO:0046903
GO:0048856
GO:0051453
GO:0055085
GO:0070050
GO:0070062
GO:2001150
GO:2001225
HMNXSV003045014
ILMN_1662795
ILMN_2199439
PH_hs_0009339
PH_hs_0031884
TC08000531.hg
Y00339_s_at
g179794_3p_at
p33840
Participates
as a component of
CA2:Zn2+ [cytosol] (Homo sapiens)
Inferred To
CAH3 [cytosol]
(Drosophila melanogaster)
CA2 [cytosol]
(Bos taurus)
CA2 [cytosol]
(Canis familiaris)
CA2 [cytosol]
(Danio rerio)
CA2 [cytosol]
(Gallus gallus)
CA2 [cytosol]
(Mus musculus)
CA2 [cytosol]
(Plasmodium falciparum)
CA2 [cytosol]
(Rattus norvegicus)
CA2 [cytosol]
(Sus scrofa)
cah-6 [cytosol]
(Caenorhabditis elegans)
ca2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000058.1
ZINC - World Drugs
CAH2_HUMAN
Guide to Pharmacology - Targets
3092
OpenTargets
ENSG00000104267
ZINC - FDA approved
CAH2_HUMAN
ZINC - Substances
CAH2_HUMAN
ZINC target
P00918
ZINC - Biogenic
CAH2_HUMAN
PRO
P00918
PDB
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3RYX
,
2HL4
,
5TFX
,
6OUK
,
1CVD
,
6T7U
,
3MHI
,
6OUM
,
5BNL
,
1BNN
,
5U0G
,
3S9T
,
3L14
,
4ZX0
,
4Q90
,
4RUZ
,
2CBC
,
5FNJ
,
1LZV
,
3S74
,
5JEH
,
6LUV
,
1CRA
,
6BBS
,
1TH9
,
6YH7
,
3M1J
,
5FLO
,
3OKU
,
5WLR
,
5FDC
,
7QSI
,
1CCS
,
1FQM
,
6KLZ
,
2NWY
,
5Y2S
,
1ZSB
,
5DSP
,
5L6T
,
7JNZ
,
1MUA
,
1RZE
,
6I0W
,
3M40
,
3HKN
,
6SBM
,
4Q7W
,
2NXS
,
1G4J
,
5NY1
,
7Y2L
,
1G0F
,
7K6L
,
4CA2
,
3D9Z
,
4E3F
,
3IBU
,
3V3H
,
6RIG
,
6LV5
,
3ML2
,
4CQ0
,
5AMD
,
6YZQ
,
6ROB
,
6IC2
,
6ROE
,
6WKA
,
2EU3
,
4Z1E
,
4BCW
,
6SD7
,
5NEA
,
2FMG
,
5JEP
,
4QJM
,
5SZ1
,
1FSQ
,
9CA2
,
7MU3
,
6OUD
,
6BC9
,
1G48
,
1UGE
,
1BN3
,
5NXM
,
1DCA
,
5FDI
,
6YH8
,
3U7C
,
2EU2
,
4JSW
,
3RG4
,
5T71
,
6UFD
,
5EHE
,
6YHC
,
2WEJ
,
4E4A
,
6CEH
,
7QBH
,
1CCU
,
2WD2
,
1IF4
,
7JOB
,
1BIC
,
4LHI
,
6OUB
,
3D92
,
6CA2
,
4QIY
,
4MTY
,
5M78
,
6YH4
,
1FQR
,
7Y2O
,
3TVO
,
6RS5
,
5E2R
,
3RYY
,
4HBA
,
6RH4
,
1UGD
,
6C7W
,
5NXG
,
4WW6
,
7QGY
,
6GDC
,
6YZX
,
3R16
,
4G0C
,
2CBE
,
3MNA
,
6RMY
,
3S78
,
3P3J
,
1BCD
,
4PQ7
,
6RSZ
,
8FQX
,
2VVA
,
3HKT
,
6CJV
,
7K6I
,
5WLV
,
6SDS
,
7Y2I
,
3DVB
,
3BL1
,
6LV2
,
3N2P
,
3S75
,
1I8Z
,
2FOS
,
6OUJ
,
1H4N
,
4Q09
,
3V3G
,
4MLX
,
3T82
,
3TMJ
,
5BRU
,
3RYZ
,
6KM5
,
4JSZ
,
7ONV
,
7OK8
,
8AA6
,
6SEY
,
2AX2
,
4RIV
,
4RUY
,
2WD3
,
7JOC
,
4WL4
,
7Y2T
,
2CA2
,
1RAY
,
6XVH
,
6RVF
,
1XPZ
,
3KKX
,
3K7K
,
5FNI
,
5J8Z
,
1G52
,
6YH5
,
5E2S
,
4QTL
,
6C7X
,
6YJ3
,
4PYX
,
1CNC
,
4K0Z
,
6UGN
,
2Q1B
,
4E5Q
,
8EXC
,
3R17
,
3M1W
,
6VJ3
,
6G3Q
,
1CVF
,
6PEA
,
5SZ4
,
6E8P
,
8FQY
,
4KUW
,
4L5W
,
4PXX
,
5NXV
,
7SUW
,
7OYM
,
5OGO
,
8CA2
,
2VVB
,
7K6J
,
6XWZ
,
1G0E
,
7BFA
,
1T9N
,
3QYK
,
6YKC
,
4FPT
,
6RNP
,
6G6T
,
7Y2J
,
7ORP
,
6LV3
,
5TXY
,
6B4D
,
5N1R
,
2ABE
,
5THN
,
5EHV
,
7JO2
,
6KM2
,
2NWZ
,
1FQN
,
5NYA
,
6OTQ
,
6YHA
,
4BF1
,
1LUG
,
5JGS
,
1TG9
,
5EH7
,
4Q81
,
6RG4
,
6RM1
,
6RRG
,
1CNB
,
3BET
,
3N0N
,
6MBV
,
7Y2N
,
6RMP
,
6MBY
,
4QK1
,
6YZU
,
6LV9
,
1ZGF
,
3PJJ
,
3V2J
,
3HS4
,
3M5E
,
1LGD
,
1HEA
,
5EKM
,
3T83
,
3PO6
,
1F2W
,
3HKQ
,
5FLS
,
3T85
,
4YYT
,
1UGG
,
6SDJ
,
5EOI
,
5LLC
,
2CBA
,
3OIL
,
4Q7P
,
1FSR
,
5WLU
,
4YGN
,
3MMF
,
1LG5
,
7U5W
,
3P5A
,
6OUH
,
4YWP
,
7CA2
,
2AW1
,
2FOQ
,
8CR0
,
6HR3
,
1FR7
,
5A6H
,
1BV3
,
4Q83
,
6UFC
,
5JGT
,
1CNH
,
4E3H
,
7JO3
,
6YHB
,
3V3I
,
5U0E
,
3IGP
,
3KIG
,
6RG5
,
1TEU
,
8B29
,
5EH8
,
4KV0
,
1YO0
,
1I9Q
,
3M5S
,
1G45
,
1CAK
,
4RIU
,
6RRI
,
5N0E
,
3DD8
,
5AML
,
4RUX
,
1ZSC
,
6D1L
,
3RG3
,
5E2K
,
1UGC
,
5JDV
,
6SAS
,
1IF8
,
1ZFK
,
3M1Q
,
4QK2
,
6HD2
,
6GM9
,
4QEF
,
2NNG
,
6LVA
,
6RMX
,
7QGX
,
6YZW
,
3RZ7
,
6GCY
,
1BNT
,
5SZ3
,
4Q7S
,
5E28
,
8BZZ
,
3P3H
,
2QO8
,
5OGN
,
5DRS
,
6SDL
,
2CBB
,
1CVC
,
7Y2H
,
3ZP9
,
3PYK
,
4RH2
,
5NXP
,
4QSI
,
3BL0
,
4R5A
,
7U5X
,
3P5L
,
4Q08
,
6OUI
ZINC - Investigational
CAH2_HUMAN
ZINC - Metabolites
CAH2_HUMAN
IntEnz
4.2.1.1
HPA
ENSG00000104267-CA2
GeneCards
P00918
Ensembl
ENSG00000104267
,
ENST00000285379
,
ENSP00000285379
Pharos - Targets
P00918
ZINC - Predictions - Purchasable
CAH2_HUMAN
Orphanet
15388
HMDB Protein
HMDBP02058
© 2024
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