Escape of antigens from phagosome to cytosol

Stable Identifier
R-HSA-1236972
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
phagolysosome, cytosol
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Escape of antigens from phagosome to cytosol
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Upon phagolysosomal proteolysis the phagocytosed proteins still need to gain access to the cytosol for proteasomal access, transport into the ER and loading onto MHC class I. The mechanism for this escape of phagocytosed antigens remain unknown.

Literature References
PubMed ID Title Journal Year
8612129 In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter

Bruce, AT, Levitsky, HI, Pardoll, DM, Huang, AY

Immunity 1996
7809629 A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules

Rock, KL, Kovacsovics-Bankowski, M

Science 1995
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Authored
Garapati, P V  (2011-03-28)
Reviewed
English, L  (2011-05-13)
Desjardins, M  (2011-05-13)
Created
Garapati, P V  (2011-03-28)
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