Proteasomal clevage of exogenous antigen

Stable Identifier
R-HSA-1236970
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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Exogenous antigens are thought to be processed for cross-presentation in much the same manner as endogenous proteins once they enter the cytosolic pathway (Rock et al. 2010). Immunoproteasome components are the major proteases involved in generating the antigenic fragments. The precurssor peptides are further trimmed by cytosolic aminopeptidases and shuttled to ER through TAP for MHC class I loading.

Literature References
PubMed ID Title Journal Year
16818754 Role of immunoproteasomes in cross-presentation

Addey, C, Millrain, M, Gallimore, A, Scott, D, Cerundolo, V, Dyson, J, Salio, M, James, E, Palmowski, MJ, Simpson, E, Gileadi, U

J Immunol 2006
20028659 Proteases in MHC class I presentation and cross-presentation

Rock, KL, Farfán-Arribas, DJ, Shen, L

J Immunol 2010
Participants
Participates
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Orthologous Events
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