Proteasomal clevage of exogenous antigen (26S proteasome catalyst)

Stable Identifier
R-HSA-1236970
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Proteasomal clevage of exogenous antigen (26S proteasome catalyst)
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Exogenous antigens are thought to be processed for cross-presentation by the 26S proteasome in much the same manner as endogenous proteins once they enter the cytosolic pathway (Rock et al. 2010). Additionally, exogenous antigens can be processed by the immunoproteasome, as described in the reaction catalyzed by immunoproteasomes (Palmowski et al. 2006). The precurssor peptides are further trimmed by cytosolic aminopeptidases and shuttled to ER through TAP for MHC class I loading.
Literature References
PubMed ID Title Journal Year
16818754 Role of immunoproteasomes in cross-presentation

Addey, C, Millrain, M, Gallimore, A, Scott, D, Cerundolo, V, Dyson, J, Salio, M, James, E, Palmowski, MJ, Simpson, E, Gileadi, U

J Immunol 2006
20028659 Proteases in MHC class I presentation and cross-presentation

Rock, KL, Farfán-Arribas, DJ, Shen, L

J Immunol 2010
Participants
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Output
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as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Bos taurus)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Caenorhabditis elegans)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Canis familiaris)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Danio rerio)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Dictyostelium discoideum)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Drosophila melanogaster)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Gallus gallus)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Mus musculus)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Plasmodium falciparum)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Rattus norvegicus)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Saccharomyces cerevisiae)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Schizosaccharomyces pombe)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Sus scrofa)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Xenopus tropicalis)
Authored
Garapati, P V  (2011-03-28)
Reviewed
English, L  (2011-05-13)
Desjardins, M  (2011-05-13)
Created
Garapati, P V  (2011-03-28)
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