Maturation of phagosome into phagolysosome

Stable Identifier
R-HSA-1236963
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
phagocytic vesicle, phagolysosome
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Maturation of phagosome into phagolysosome
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Following fission of the phagosome vesicle from the plasma membrane, the phagosome undergoes maturation by a series of fusion and fission events, fusing with late endosomes and ultimately lysosomes, to form a phagolysosome.

fuses sequentially with sorting/early endosomes, late endosomes and finally lysosomes to acquire degradative capabilities. This process is referred to as phagosome maturation.

Literature References
PubMed ID Title Journal Year
12061891 Phagosome maturation: aging gracefully

Vieira, OV, Botelho, RJ, Grinstein, S

Biochem J 2002
18331591 Contributions of proteomics to understanding phagosome maturation

Rogers, LD, Foster, LJ

Cell Microbiol 2008
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Authored
Garapati, P V  (2011-03-28)
Reviewed
Desjardins, M  (2011-05-13)
English, L  (2011-05-13)
Created
Garapati, P V  (2011-03-28)