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Maturation of phagosome into phagolysosome
Stable Identifier
R-HSA-1236963
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
phagocytic vesicle
,
phagolysosome
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
Cross-presentation of particulate exogenous antigens (phagosomes) (Homo sapiens)
Maturation of phagosome into phagolysosome (Homo sapiens)
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Following fission of the phagosome vesicle from the plasma membrane, the phagosome undergoes maturation by a series of fusion and fission events, fusing with late endosomes and ultimately lysosomes, to form a phagolysosome.
fuses sequentially with sorting/early endosomes, late endosomes and finally lysosomes to acquire degradative capabilities. This process is referred to as phagosome maturation.
Literature References
PubMed ID
Title
Journal
Year
18331591
Contributions of proteomics to understanding phagosome maturation
Foster, LJ
,
Rogers, LD
Cell Microbiol
2008
12061891
Phagosome maturation: aging gracefully
Botelho, RJ
,
Vieira, OV
,
Grinstein, S
Biochem J
2002
Participants
Input
Exogenous Particulate antigen (Ag) [phagocytic vesicle]
Output
Exogenous Particulate antigen (Ag) [phagolysosome]
Participates
as an event of
Cross-presentation of particulate exogenous antigens (phagosomes) (Homo sapiens)
Authored
Garapati, P V (2011-03-28)
Reviewed
English, L (2011-05-13)
Desjardins, M (2011-05-13)
Created
Garapati, P V (2011-03-28)
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