Dendritic cells (DCs) and macrophages recognize and phagocytose apoptotic cells/invading microorganisms using a variety of receptors including lectins, Mannose receptor (MR) (Stahl & Ezekowitz. 1998), CD36 (Savill 1997), CD14 (Devitt et al. 1998), scavenger receptor A (SR-A) (Platt et al. 1996) and integrin alphaVbeta5 (Savill et al. 1992, Savilli et al. 1990), then cross-present cell-associated antigens to CD8+ T cells. Ligands on apoptotic cell like sugars, phosphatidylserine and surface-bound thrombospondin (TSP) are recognized by these receptors and induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle.
Albert, ML, Pearce, SF, Francisco, LM, Sauter, B, Roy, P, Silverstein, RL, Bhardwaj, N
Rogers, LD, Foster, LJ
Lin, ML, Zhan, Y, Villadangos, JA, Lew, AM
Pfeifer, JD, Wick, MJ, Roberts, RL, Findlay, K, Normark, SJ, Harding, CV
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