Reactome | Interaction of particulate antigens with dendritic cell receptors

Interaction of particulate antigens with dendritic cell receptors

Stable Identifier

R-HSA-1236958

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

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Interaction of particulate antigens with dendritic cell receptors

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Dendritic cells (DCs) and macrophages recognize and phagocytose apoptotic cells/invading microorganisms using a variety of receptors including lectins, Mannose receptor (MR) (Stahl & Ezekowitz. 1998), CD36 (Savill 1997), CD14 (Devitt et al. 1998), scavenger receptor A (SR-A) (Platt et al. 1996) and integrin alphaVbeta5 (Savill et al. 1992, Savilli et al. 1990), then cross-present cell-associated antigens to CD8+ T cells. Ligands on apoptotic cell like sugars, phosphatidylserine and surface-bound thrombospondin (TSP) are recognized by these receptors and induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle.

Literature References

PubMed ID	Title	Journal	Year
9763615	Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes Albert, ML, Pearce, SF, Francisco, LM, Sauter, B, Roy, P, Silverstein, RL, Bhardwaj, N	J Exp Med	1998
18331591	Contributions of proteomics to understanding phagosome maturation Rogers, LD, Foster, LJ	Cell Microbiol	2008
18268517	The cell biology of cross-presentation and the role of dendritic cell subsets Lin, ML, Zhan, Y, Villadangos, JA, Lew, AM	Immunol Cell Biol	2008
7678924	Phagocytic processing of bacterial antigens for class I MHC presentation to T cells Pfeifer, JD, Wick, MJ, Roberts, RL, Findlay, K, Normark, SJ, Harding, CV	Nature	1993