Interaction of particulate antigens with dendritic cell receptors

Stable Identifier
R-HSA-1236958
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dendritic cells (DCs) and macrophages recognize and phagocytose apoptotic cells/invading microorganisms using a variety of receptors including lectins, Mannose receptor (MR) (Stahl & Ezekowitz. 1998), CD36 (Savill 1997), CD14 (Devitt et al. 1998), scavenger receptor A (SR-A) (Platt et al. 1996) and integrin alphaVbeta5 (Savill et al. 1992, Savilli et al. 1990), then cross-present cell-associated antigens to CD8+ T cells. Ligands on apoptotic cell like sugars, phosphatidylserine and surface-bound thrombospondin (TSP) are recognized by these receptors and induce rearrangements in the actin cytoskeleton that lead to the internalization of the particle.

Literature References
PubMed ID Title Journal Year
9763615 Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes

Albert, ML, Pearce, SF, Francisco, LM, Sauter, B, Roy, P, Silverstein, RL, Bhardwaj, N

J Exp Med 1998
18331591 Contributions of proteomics to understanding phagosome maturation

Rogers, LD, Foster, LJ

Cell Microbiol 2008
18268517 The cell biology of cross-presentation and the role of dendritic cell subsets

Lin, ML, Zhan, Y, Villadangos, JA, Lew, AM

Immunol Cell Biol 2008
7678924 Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

Pfeifer, JD, Wick, MJ, Roberts, RL, Findlay, K, Normark, SJ, Harding, CV

Nature 1993
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created