Exogenous soluble antigen targeted to more stable early endosome

Stable Identifier
R-HSA-1236940
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Within the endosome the receptor and cargo separate and the receptor recycles back to the cell surface. Soluble antigens are targeted into the stable early endosome lumen for efficient cross presentation. Early endosomes are mildly acidic and relatively poor in proteases.

Literature References
PubMed ID Title Journal Year
15592474 Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells

Ackerman, AL, Kyritsis, C, Tampé, R, Cresswell, P

Nat Immunol 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created