Reactome | HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane]

Stable Identifier

R-HSA-1236799

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

1C07_HUMAN, HLA-C

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P10321 HLA-C

Gene Names

HLA-C, HLAC

Chain

signal peptide:1-24, chain:25-366

Reference Genes

BioGPS Gene:3107 HLA-C

COSMIC (genes):HLA-C HLA-C

CTD Gene:3107 HLA-C

dbSNP Gene:3107 HLA-C

ENSEMBL:ENSG00000204525 HLA-C

HGNC:4933 HLA-C

KEGG Gene (Homo sapiens):3107 HLA-C

Monarch:3107 HLA-C

NCBI Gene:3107 HLA-C

UCSC:P10321 HLA-C

Reference Transcript

RefSeq:NM_002117.5 HLA-C

Other Identifiers

11715316_x_at

17017126

17029003

216526_x_at

2900985

2900990

2901160

2901186

2901190

2901216

2901249

2901470

2901471

2901631

2948892

2948893

2948894

2948896

2948897

2948899

2948901

2948904

2948905

2948906

2948907

2948908

2948909

2948910

2948914

2948915

2948918

2948919

2948945

2948946

2948951

3107

8124901

8178489

A_24_P298409

A_33_P3330109

GO:0000139

GO:0002250

GO:0002376

GO:0002474

GO:0002479

GO:0002480

GO:0002486

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005768

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0005887

GO:0006810

GO:0006950

GO:0006955

GO:0007165

GO:0008150

GO:0009986

GO:0012507

GO:0016020

GO:0016021

GO:0016032

GO:0016192

GO:0019882

GO:0030667

GO:0030670

GO:0031410

GO:0031901

GO:0032991

GO:0042605

GO:0042612

GO:0043226

GO:0043312

GO:0044403

GO:0045087

GO:0046977

GO:0050776

GO:0055038

GO:0060333

GO:0060337

GO:0070062

GO:0071556

Hs.277477.2.S1_3p_x_at

ILMN_2150787

Participant Of

hasMember

Class I MHC heavy chain (MHC HC) [early endosome membrane]

Other forms of this molecule

HLA-C [secretory granule membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [phagocytic vesicle membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [ER to Golgi transport vesicle membrane]

HLA-C [plasma membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [Golgi membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]

Cross References

RefSeq

NP_002108.4

OpenTargets

ENSG00000204525

HPA

ENSG00000204525-HLA-C

GeneCards

P10321

Ensembl

ENST00000376228, ENSP00000365402, ENSG00000204525

PRO

P10321

PDB

5VGE, 5W6A, 5W67, 1EFX, 4NT6, 5VGD, 3BZF, 1QQD, 6JTO, 1IM9, 5W69

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61769 B2M	11	B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [early endosome membrane] (R-HSA-182298) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [plasma membrane] (R-HSA-167743)	0.779	6
UniProt:P43626 KIR2DL1	1	KIR2DL1 [plasma membrane] (R-HSA-199538)	0.722	12
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.527	2