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HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane]
Stable Identifier
R-HSA-1236799
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome membrane
Synonyms
1C07_HUMAN, HLA-C
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
Endosomal/Vacuolar pathway (Homo sapiens)
Loading of antigen peptide onto MHC class I molecule (Homo sapiens)
Antigen peptide bound class I MHC [early endosome membrane] (Homo sapiens)
Class I MHC:B2M [early endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane] (Homo sapiens)
Class I MHC:B2M [early endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane] (Homo sapiens)
Translocation of peptide bound MHC class I complex to cell surface (Homo sapiens)
Antigen peptide bound class I MHC [early endosome membrane] (Homo sapiens)
Class I MHC:B2M [early endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane] (Homo sapiens)
Trimming of peptides by IRAP in endocytic vesicles (Homo sapiens)
IRAP in complex with MHC class I [early endosome membrane] (Homo sapiens)
Class I MHC:B2M [early endosome membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [early endosome membrane] (Homo sapiens)
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10321 HLA-C
Gene Names
HLA-C, HLAC
Chain
signal peptide:1-24, chain:25-366
Reference Genes
BioGPS Gene:3107 HLA-C
COSMIC (genes):HLA-C HLA-C
CTD Gene:3107 HLA-C
dbSNP Gene:3107 HLA-C
ENSEMBL:ENSG00000204525 HLA-C
HGNC:4933 HLA-C
KEGG Gene (Homo sapiens):3107 HLA-C
Monarch:3107 HLA-C
NCBI Gene:3107 HLA-C
UCSC:P10321 HLA-C
Reference Transcript
RefSeq:NM_002117.5 HLA-C
Other Identifiers
11715316_x_at
17017126
17029003
216526_x_at
2900985
2900990
2901160
2901186
2901190
2901216
2901249
2901470
2901471
2901631
2948892
2948893
2948894
2948896
2948897
2948899
2948901
2948904
2948905
2948906
2948907
2948908
2948909
2948910
2948914
2948915
2948918
2948919
2948945
2948946
2948951
3107
8124901
8178489
A_24_P298409
A_33_P3330109
GO:0000139
GO:0002250
GO:0002376
GO:0002474
GO:0002479
GO:0002480
GO:0002486
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005887
GO:0006810
GO:0006950
GO:0006955
GO:0007165
GO:0008150
GO:0009986
GO:0012507
GO:0016020
GO:0016021
GO:0016032
GO:0016192
GO:0019882
GO:0030667
GO:0030670
GO:0031410
GO:0031901
GO:0032991
GO:0042605
GO:0042612
GO:0043226
GO:0043312
GO:0044403
GO:0045087
GO:0046977
GO:0050776
GO:0055038
GO:0060333
GO:0060337
GO:0070062
GO:0071556
Hs.277477.2.S1_3p_x_at
ILMN_2150787
Participant Of
hasMember
Class I MHC heavy chain (MHC HC) [early endosome membrane]
Other forms of this molecule
HLA-C [secretory granule membrane]
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [phagocytic vesicle membrane]
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [ER to Golgi transport vesicle membrane]
HLA-C [plasma membrane]
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [Golgi membrane]
HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]
Cross References
RefSeq
NP_002108.4
OpenTargets
ENSG00000204525
HPA
ENSG00000204525-HLA-C
GeneCards
P10321
Ensembl
ENST00000376228
,
ENSP00000365402
,
ENSG00000204525
PRO
P10321
PDB
5VGE
,
5W6A
,
5W67
,
1EFX
,
4NT6
,
5VGD
,
3BZF
,
1QQD
,
6JTO
,
1IM9
,
5W69
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61769 B2M
11
B2M(21-119) [specific granule lumen]
(R-HSA-6806144)
B2M(21-119) [early endosome membrane]
(R-HSA-182298)
B2M(21-119) [extracellular region]
(R-HSA-1302721)
B2M(21-119) [tertiary granule lumen]
(R-HSA-6800179)
B2M(21-119) [phagocytic vesicle membrane]
(R-HSA-1236891)
B2M(21-119) [recycling endosome membrane]
(R-HSA-8863880)
B2M(21-119) [early endosome lumen]
(R-HSA-1236827)
B2M(21-119) [ER to Golgi transport vesicle membrane]
(R-HSA-983378)
B2M(21-119) [Golgi membrane]
(R-HSA-983403)
B2M(21-119) [endoplasmic reticulum lumen]
(R-HSA-983063)
B2M(21-119) [plasma membrane]
(R-HSA-167743)
0.779
6
UniProt:P43626 KIR2DL1
1
KIR2DL1 [plasma membrane]
(R-HSA-199538)
0.722
12
UniProt:Q9UI95 MAD2L2
1
MAD2L2 [nucleoplasm]
(R-HSA-59092)
0.527
2
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