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HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane]
Stable Identifier
R-HSA-1235089
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
HLA-DRB1, 2B1B_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
PD-1 signaling (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Insertion of MHC II:Ii complex in to the plasma membrane (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
LAG3 (CD233) binds MHC II (Homo sapiens)
LAG3:MHC II [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Recruitment of clathrin coated vesicle by Ii (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
peptide loaded MHC class II [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Change of PKC theta conformation (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Phosphorylation of PLC-gamma1 (Homo sapiens)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Phosphorylation of SLP-76 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Phosphorylation of TBSMs in LAT (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Activation of Lck (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Inactivation of LCK by PTPN22 (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Inactivation of Lck by Csk (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
Activation of ZAP-70 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
PTPN22 dephosphorylates ZAP70 (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Phosphorylation of ZAP-70 by Lck (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Expression of IFNG-stimulated genes (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DRB1-11 beta chain [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20039 HLA-DRB1
Gene Names
HLA-DRB1
Chain
signal peptide:1-29, chain:30-266
Reference Genes
BioGPS Gene:3123 HLA-DRB1
COSMIC (genes):HLA-DRB1 HLA-DRB1
CTD Gene:3123 HLA-DRB1
dbSNP Gene:3123 HLA-DRB1
ENSEMBL:ENSG00000196126.12 HLA-DRB1
KEGG Gene (Homo sapiens):3123 HLA-DRB1
Monarch:3123 HLA-DRB1
NCBI Gene:3123 HLA-DRB1
UCSC:P20039 HLA-DRB1
Reference Transcript
RefSeq:XM_011547738.2 HLA-DRB1
RefSeq:NM_002124.3 HLA-DRB1
RefSeq:NM_001243965.1 HLA-DRB1
Participates
as a member of
HLA II beta chain [plasma membrane] (Homo sapiens)
Other forms of this molecule
HLA class II histocompatibility antigen, DRB1-11 beta chain [integral component of lumenal side of endoplasmic reticulum membrane]
HLA class II histocompatibility antigen, DRB1-11 beta chain [ER to Golgi transport vesicle membrane]
HLA class II histocompatibility antigen, DRB1-11 beta chain [Golgi membrane]
HLA class II histocompatibility antigen, DRB1-11 beta chain [trans-Golgi network membrane]
HLA class II histocompatibility antigen, DRB1-11 beta chain [transport vesicle membrane]
HLA class II histocompatibility antigen, DRB1-11 beta chain [clathrin-coated endocytic vesicle membrane]
HLA class II histocompatibility antigen, DRB1-11 beta chain [endocytic vesicle membrane]
HLA class II histocompatibility antigen, DRB1-11 beta chain [lysosomal membrane]
Cross References
RefSeq
NP_002115.2
,
XP_011546040.1
,
NP_001230894.1
OpenTargets
ENSG00000196126
GeneCards
P20039
PRO
P20039
Pharos - Targets
P20039
PDB
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