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HIF1A [nucleoplasm]
Stable Identifier
R-HSA-1234135
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Hypoxia-inducible factor 1-alpha, HIF1A_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P46531 NOTCH1
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Homo sapiens)
HIF1A [nucleoplasm] (Homo sapiens)
Circadian Clock (Homo sapiens)
Expression of RORA (ROR-alpha) (Homo sapiens)
HIF1A [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Differentiation of keratinocytes in interfollicular epidermis in mammalian skin (Homo sapiens)
Keratinocyte of spinosum layer differentiates into keratinocyte of granulosum layer in interfollicular epidermis (Homo sapiens)
HIF1A [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
NICD1 binds HIF1A (Homo sapiens)
HIF1A [nucleoplasm] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
STAT3 nuclear events downstream of ALK signaling (Homo sapiens)
ALK- and STAT3-dependent HIF1A gene expression (Homo sapiens)
HIF1A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16665 HIF1A
Gene Names
HIF1A, BHLHE78, MOP1, PASD8
Chain
chain:1-826
Reference Genes
BioGPS Gene:3091 HIF1A
COSMIC (genes):HIF1A HIF1A
CTD Gene:3091 HIF1A
dbSNP Gene:3091 HIF1A
ENSEMBL:ENSG00000100644 HIF1A
ENSEMBL_homo_sapiens_GENE:ENSG00000100644.17 HIF1A
HGNC:4910 HIF1A
KEGG Gene (Homo sapiens):3091 HIF1A
Monarch:3091 HIF1A
NCBI Gene:3091 HIF1A
OMIM:603348 HIF1A
UCSC:Q16665 HIF1A
Reference Transcript
RefSeq:NM_001243084.1 HIF1A
RefSeq:NM_181054.2 HIF1A
RefSeq:NM_001530.3 HIF1A
Other Identifiers
1039_s_at
11718757_s_at
11718758_a_at
11718759_x_at
11747800_a_at
11749123_a_at
11749648_a_at
11749649_x_at
11755737_x_at
16785058
200989_PM_at
200989_at
3091
3539073
3539074
3539075
3539083
3539084
3539085
3539087
3539088
3539089
3539090
3539091
3539093
3539094
3539095
3539097
3539098
3539099
3539100
3539102
3539103
3539104
3539105
75276_at
7974851
A_14_P117087
A_24_P56388
A_33_P3231277
GE59057
GO:0000302
GO:0000785
GO:0000791
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001216
GO:0001217
GO:0001223
GO:0001228
GO:0001525
GO:0001568
GO:0001666
GO:0001678
GO:0001755
GO:0001837
GO:0001892
GO:0001922
GO:0001938
GO:0001944
GO:0001947
GO:0002039
GO:0002052
GO:0002062
GO:0002067
GO:0002071
GO:0002248
GO:0002376
GO:0003151
GO:0003208
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005929
GO:0005975
GO:0006089
GO:0006091
GO:0006110
GO:0006351
GO:0006355
GO:0006357
GO:0006879
GO:0006914
GO:0006915
GO:0006954
GO:0007005
GO:0007018
GO:0007165
GO:0007405
GO:0007595
GO:0008542
GO:0010039
GO:0010468
GO:0010508
GO:0010573
GO:0010575
GO:0010628
GO:0010629
GO:0010634
GO:0012501
GO:0014850
GO:0016239
GO:0016604
GO:0016607
GO:0016922
GO:0019896
GO:0019899
GO:0019901
GO:0019904
GO:0021502
GO:0021987
GO:0023052
GO:0030154
GO:0030279
GO:0030282
GO:0030502
GO:0030949
GO:0031514
GO:0031625
GO:0031929
GO:0032007
GO:0032364
GO:0032722
GO:0032909
GO:0032963
GO:0032991
GO:0034599
GO:0035162
GO:0035773
GO:0035774
GO:0036211
GO:0042060
GO:0042127
GO:0042541
GO:0042593
GO:0042826
GO:0043066
GO:0043226
GO:0043524
GO:0043536
GO:0043565
GO:0045648
GO:0045766
GO:0045821
GO:0045893
GO:0045926
GO:0045944
GO:0046716
GO:0046886
GO:0046982
GO:0046983
GO:0048514
GO:0048546
GO:0048593
GO:0048856
GO:0048870
GO:0050877
GO:0051000
GO:0051216
GO:0051402
GO:0051541
GO:0051879
GO:0055065
GO:0055086
GO:0060574
GO:0061030
GO:0061072
GO:0061298
GO:0061629
GO:0070101
GO:0070243
GO:0070244
GO:0070888
GO:0071347
GO:0071456
GO:0071542
GO:0090575
GO:0097152
GO:0097411
GO:0098586
GO:0098772
GO:0140110
GO:0140537
GO:1900017
GO:1901135
GO:1901526
GO:1902894
GO:1902895
GO:1903377
GO:1903715
GO:1904115
GO:2000273
GO:2000378
GO:2000434
GO:2001054
HMNXSV003055761
ILMN_1681283
ILMN_1763260
ILMN_2379788
PH_hs_0028366
TC14002197.hg
U22431_s_at
g4504384_3p_at
Participates
as a member of
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
HIF-alpha [nucleoplasm] (Homo sapiens)
HIF1A,EPAS1 [nucleoplasm] (Homo sapiens)
as an output of
ALK- and STAT3-dependent HIF1A gene expression (Homo sapiens)
as a component of
mNICD1:HIF1A [nucleoplasm] (Homo sapiens)
NICD1:HIF1A [nucleoplasm] (Homo sapiens)
as an input of
mNICD1 binds HIF1A (Homo sapiens)
NICD1 binds HIF1A (Homo sapiens)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Homo sapiens)
This entity regulates
Positively
Expression of RORA (ROR-alpha)
(Homo sapiens)
Other forms of this molecule
HN-HIF1A [cytosol]
2xHP-HIF1A [nucleoplasm]
2xHP-HIF1A [cytosol]
p-Y565,S797-HIF1A [cytosol]
p-Y565-HIF1A [cytosol]
HIF1A [cytosol]
Inferred To
sima [nucleoplasm]
(Drosophila melanogaster)
HIF1A [nucleoplasm]
(Bos taurus)
HIF1A [nucleoplasm]
(Canis familiaris)
HIF1A [nucleoplasm]
(Gallus gallus)
HIF1A [nucleoplasm]
(Sus scrofa)
hif1a [nucleoplasm]
(Xenopus tropicalis)
hif-1 [nucleoplasm]
(Caenorhabditis elegans)
Hif1a [nucleoplasm]
(Mus musculus)
Hif1a [nucleoplasm]
(Rattus norvegicus)
hif1ab [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_001521.1
,
NP_001230013.1
,
NP_851397.1
ZINC - World Drugs
HIF1A_HUMAN
OpenTargets
ENSG00000100644
ZINC - FDA approved
HIF1A_HUMAN
ZINC - Substances
HIF1A_HUMAN
ZINC - Biogenic
HIF1A_HUMAN
ZINC target
Q16665
PRO
Q16665
PDB
1L8C
,
1H2M
,
6GFX
,
5LAS
,
2ILM
,
3HQU
,
6GMR
,
5L9B
,
5LA9
,
4AJY
,
1H2L
,
8HE3
,
4H6J
,
1H2K
,
1LM8
,
7LVS
,
7QGS
,
5L9V
,
8HE0
,
3HQR
,
1LQB
,
1L3E
,
5JWP
,
6YW3
ZINC - Metabolites
HIF1A_HUMAN
HPA
ENSG00000100644-HIF1A
GeneCards
Q16665
Ensembl
ENST00000539097
,
ENST00000337138
,
ENSP00000437955
,
ENSP00000323326
,
ENSG00000100644
,
ENST00000323441
,
ENSP00000338018
Pharos - Targets
Q16665
ZINC - Predictions - Purchasable
HIF1A_HUMAN
Interactors (52)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40337 VHL
3
monoSUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
VHL [nucleoplasm]
(R-HSA-1234127)
VHL [cytosol]
(R-HSA-391423)
0.962
22
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.962
20
UniProt:P27540 ARNT
1
ARNT [nucleoplasm]
(R-HSA-1234098)
0.936
13
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.922
12
UniProt:Q9H6Z9 EGLN3
2
EGLN3 [nucleoplasm]
(R-HSA-1234104)
EGLN3 [cytosol]
(R-HSA-1234115)
0.881
7
UniProt:Q9GZT9 EGLN1
1
EGLN1 [cytosol]
(R-HSA-1234108)
0.803
5
UniProt:Q15370 ELOB
2
TCEB2 [nucleoplasm]
(R-HSA-112423)
ELOB [cytosol]
(R-HSA-180551)
0.789
8
IntAct:EBI-2895491 VEGFA
0.725
6
UniProt:O60224 SSX4
0.721
5
UniProt:Q15369 ELOC
2
TCEB1 [nucleoplasm]
(R-HSA-112422)
ELOC [cytosol]
(R-HSA-180535)
0.702
5
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.688
4
UniProt:Q96KS0 EGLN2
1
EGLN2 [nucleoplasm]
(R-HSA-1234117)
0.683
3
UniProt:O00257 CBX4
2
monoSUMO1-K494-CBX4 [nucleoplasm]
(R-HSA-4551626)
CBX4 [nucleoplasm]
(R-HSA-389118)
0.674
15
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.669
3
UniProt:P41227 NAA10
0.667
3
UniProt:P40337-3 VHL
0.659
6
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.649
9
UniProt:Q8N461 FBXL16
1
FBXL16 [cytosol]
(R-HSA-8862609)
0.615
6
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.609
2
UniProt:P09467 FBP1
1
FBP1 [cytosol]
(R-HSA-70476)
0.602
5
UniProt:P14618-1 PKM
2
PolyUb-PKM-1 [cytosol]
(R-HSA-9861692)
PKM-1 [cytosol]
(R-HSA-71667)
0.591
7
UniProt:P17861 XBP1
0.591
3
UniProt:P25789 PSMA4
2
PSMA4 [nucleoplasm]
(R-HSA-174324)
PSMA4 [cytosol]
(R-HSA-68730)
0.576
4
UniProt:P11474 ESRRA
1
ESRRA [nucleoplasm]
(R-HSA-446159)
0.576
3
UniProt:MAFG Q9BRP3
0.557
3
UniProt:Q9UHD8-1 SEPTIN9
0.556
4
UniProt:Q13330 MTA1
2
MTA1 [nucleoplasm]
(R-HSA-3465550)
polySUMO2,3-K509-MTA1 [nucleoplasm]
(R-HSA-3465537)
0.556
6
UniProt:Q9HBZ2 ARNT2
1
ARNT2 [nucleoplasm]
(R-HSA-8936838)
0.547
2
UniProt:P40818 USP8
2
USP8 [cytosol]
(R-HSA-917720)
p-T945-USP8 [cytosol]
(R-HSA-1358714)
0.544
2
UniProt:O14818 PSMA7
2
PSMA7 [nucleoplasm]
(R-HSA-174351)
PSMA7 [cytosol]
(R-HSA-68736)
0.544
2
UniProt:P51450-2 Rorc
1
Rorc-2 [nucleoplasm]
(R-MMU-8949302)
0.544
2
UniProt:Q8BIF2 Rbfox3
1
Rbfox3 [nucleoplasm]
(R-MMU-9770531)
0.544
2
UniProt:P12882 MYH1
0.527
2
UniProt:P13533 MYH6
1
MYH6 [cytosol]
(R-HSA-390563)
0.527
2
UniProt:Q9UKX2 MYH2
1
MYH2 [cytosol]
(R-HSA-1449561)
0.527
2
UniProt:P11055 MYH3
1
MYH3 [cytosol]
(R-HSA-390560)
0.527
2
UniProt:Q9Y623 MYH4
0.527
2
UniProt:P68133 ACTA1
1
ACTA1 [cytosol]
(R-HSA-390534)
0.527
2
UniProt:Q92831 KAT2B
1
KAT2B [nucleoplasm]
(R-HSA-352430)
0.524
2
UniProt:Q96CJ1 EAF2
1
EAF2 [nucleoplasm]
(R-HSA-8932790)
0.524
3
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.524
3
UniProt:Q5RIX9
1
e2f7 [nucleoplasm]
(R-DRE-6798305)
0.524
2
UniProt:P23771 GATA3
2
GATA3 [nucleoplasm]
(R-HSA-996768)
PolyUb-GATA3 [nucleoplasm]
(R-HSA-6783009)
0.524
3
UniProt:P46531 NOTCH1
20
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
0.499
2
UniProt:Q9C0J9 BHLHE41
1
BHLHE41 [nucleoplasm]
(R-HSA-879703)
0.499
2
UniProt:Q9Y2N7-4 HIF3A
0.499
2
UniProt:Q61539
1
Esrrb [nucleoplasm]
(R-MMU-446173)
0.499
2
UniProt:Q99PV5 Bhlhe41
1
Bhlhe41 [nucleoplasm]
(R-MMU-879802)
0.499
3
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.499
3
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.463
3
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.463
6
UniProt:P49327 FASN
3
FASN [cytosol]
(R-HSA-199233)
decanoyl-FASN [cytosol]
(R-HSA-5655935)
FASN [cytosol]
(R-HSA-54659)
0.463
4
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