ERBB2 homodimerization

Stable Identifier
R-HSA-1227964
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
2 x ERBB2:HSP90:CDC37 => ERBB2 homodimer
ReviewStatus
5/5
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ERBB2 homodimerization
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ERBB2, present at low levels in normal cells, is overexpressed in cancer cells with ERBB2 gene amplification, leading to growth factor-independent activation of ERBB2 signaling through formation of ERBB2 homodimers (Pickl and Ries 2009, Maadi et al. 2018). It is assumed that during homodimerization, similar to normal heterodimerization with ligand-activated ERBB family members, chaperone proteins HSP90 and CDC37, as well as ERBB2IP, dissociate from ERBB2 (Borg et al. 2000, Xu et al. 2001, Citri et al. 2004).
Literature References
Participants
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Output
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as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2019-07-31)
Reviewed
Kancha, RK  (2019-09-16)
Created
Orlic-Milacic, M  (2011-03-14)
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