Recruitment of HDAC1 by p107 (RBL1)

Stable Identifier
R-HSA-1227671
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HDAC1 + p107(RBL1):E2F4:DP1 => HDAC1-p107(RBL2):E2F4:DP1
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Recruitment of HDAC1 by p107 (RBL1)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

p107 (RBL1) in complex with E2F4 and DP1 or DP2 recruits histone deacetylase HDAC1 (possibly in complex with other chromatin modification proteins) through LXCXE-like motif, shared by pocket proteins, to repress transcription of E2F target genes in early G1.

Literature References
PubMed ID Title Journal Year
9724731 The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase

Ferreira, R, Magnaghi-Jaulin, L, Robin, P, Harel-Bellan, A, Trouche, D

Proc Natl Acad Sci U S A 1998
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Recruitment of HDAC1 by p107 (RBL1) (Bos taurus)
Recruitment of HDAC1 by p107 (RBL1) (Caenorhabditis elegans)
Recruitment of HDAC1 by p107 (RBL1) (Canis familiaris)
Recruitment of HDAC1 by p107 (RBL1) (Danio rerio)
Recruitment of HDAC1 by p107 (RBL1) (Dictyostelium discoideum)
Recruitment of HDAC1 by p107 (RBL1) (Gallus gallus)
Recruitment of HDAC1 by p107 (RBL1) (Mus musculus)
Recruitment of HDAC1 by p107 (RBL1) (Rattus norvegicus)
Recruitment of HDAC1 by p107 (RBL1) (Sus scrofa)
Recruitment of HDAC1 by p107 (RBL1) (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2011-03-10)
Cite Us!