Recruitment of HDAC1 by p107 (RBL1)

Stable Identifier
R-HSA-1227671
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
HDAC1 + p107(RBL1):E2F4:DP1 => HDAC1-p107(RBL2):E2F4:DP1
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Recruitment of HDAC1 by p107 (RBL1)
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p107 (RBL1) in complex with E2F4 and DP1 or DP2 recruits histone deacetylase HDAC1 (possibly in complex with other chromatin modification proteins) through LXCXE-like motif, shared by pocket proteins, to repress transcription of E2F target genes in early G1.

Literature References
PubMed ID Title Journal Year
9724731 The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase

Ferreira, R, Magnaghi-Jaulin, L, Robin, P, Harel-Bellan, A, Trouche, D

Proc Natl Acad Sci U S A 1998
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Orthologous Events
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Recruitment of HDAC1 by p107 (RBL1) (Dictyostelium discoideum)
Recruitment of HDAC1 by p107 (RBL1) (Drosophila melanogaster)
Recruitment of HDAC1 by p107 (RBL1) (Gallus gallus)
Recruitment of HDAC1 by p107 (RBL1) (Mus musculus)
Recruitment of HDAC1 by p107 (RBL1) (Rattus norvegicus)
Recruitment of HDAC1 by p107 (RBL1) (Sus scrofa)
Authored
Orlic-Milacic, M  (2011-06-14)
Reviewed
MacPherson, D  (2011-08-25)
Created
Orlic-Milacic, M  (2011-03-10)
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