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FRAT1 [cytosol]
Stable Identifier
R-HSA-1226051
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Proto-oncogene FRAT1, FRAT1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Beta-catenin phosphorylation cascade (Homo sapiens)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Homo sapiens)
FRAT1,2:GSK3beta [cytosol] (Homo sapiens)
FRAT1,2 [cytosol] (Homo sapiens)
FRAT1 [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
FRAT1,2:GSK3beta [cytosol] (Homo sapiens)
FRAT1,2 [cytosol] (Homo sapiens)
FRAT1 [cytosol] (Homo sapiens)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
FRAT1,2:GSK3beta [cytosol] (Homo sapiens)
FRAT1,2 [cytosol] (Homo sapiens)
FRAT1 [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
FRAT proteins bind GSK3beta (Homo sapiens)
FRAT1,2 [cytosol] (Homo sapiens)
FRAT1 [cytosol] (Homo sapiens)
FRAT1,2:GSK3beta [cytosol] (Homo sapiens)
FRAT1,2 [cytosol] (Homo sapiens)
FRAT1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92837 FRAT1
Gene Names
FRAT1
Chain
chain:1-279
Reference Genes
BioGPS Gene:10023 FRAT1
COSMIC (genes):FRAT1 FRAT1
CTD Gene:10023 FRAT1
dbSNP Gene:10023 FRAT1
ENSEMBL:ENSG00000165879 FRAT1
HGNC:3944 FRAT1
KEGG Gene (Homo sapiens):10023 FRAT1
Monarch:10023 FRAT1
NCBI Gene:10023 FRAT1
OMIM:602503 FRAT1
UCSC:Q92837 FRAT1
Reference Transcript
RefSeq:NM_005479.3 FRAT1
Other Identifiers
0002470471
0004150647
10023
11743949_s_at
11745037_s_at
11745038_s_at
16707955
219889_PM_at
219889_at
3259789
3259790
3259791
3259792
3259793
3259794
3259795
3259796
3302234
7929616
81909_at
A_14_P124508
A_33_P3261173
A_33_P3367899
GE58367
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0006810
GO:0006913
GO:0007165
GO:0007267
GO:0008150
GO:0015031
GO:0016055
GO:0043226
GO:0043231
GO:0046825
GO:0060070
GO:0090263
GO:1904886
HMNXSV003053602
ILMN_1736180
ILMN_1781416
ILMN_3202976
PH_hs_0007146
TC10000692.hg
g4885246_3p_at
Participates
as a member of
FRAT1,2 [cytosol] (Homo sapiens)
Inferred To
FRAT1 [cytosol]
(Bos taurus)
FRAT1 [cytosol]
(Canis familiaris)
FRAT1 [cytosol]
(Gallus gallus)
FRAT1 [cytosol]
(Sus scrofa)
Frat1 [cytosol]
(Mus musculus)
Peg12 [cytosol]
(Rattus norvegicus)
frat1 [cytosol]
(Xenopus tropicalis)
gbp [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_005470.2
OpenTargets
ENSG00000165879
HPA
ENSG00000165879-FRAT1
GeneCards
Q92837
Ensembl
ENSG00000165879
,
ENSP00000360060
,
ENST00000371021
PRO
Q92837
Pharos - Targets
Q92837
Orphanet
27020
PDB
4AFJ
,
5OY4
,
3ZRM
,
3ZRK
,
1GNG
,
3ZRL
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.813
5
UniProt:P49840 GSK3A
3
GSK3A [cytosol]
(R-HSA-198326)
p-S21-GSK3A [cytosol]
(R-HSA-198352)
p-Y279-GSK3A [cytosol]
(R-HSA-9635490)
0.669
3
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
AXIN1 [cytosol]
(R-HSA-195249)
p-T519,S524,S531-AXIN1 [cytosol]
(R-HSA-206040)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
0.525
3
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