Nitric oxide is oxidized to nitrate

Stable Identifier
R-HSA-1222723
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
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Nitric oxide is oxidized to nitrate
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Heme proteins, especially the truncated globin GlbN in Mtb possess oxygen-dependent nitric oxide dioxygenase activity, where the heme that is oxidized to ferriheme in the process will need to be reduced in a second step to activate the protein again. The responsible heme protein reductase is unknown (Ouellet et al. 2002, Pathania et al. 2002).

Literature References
PubMed ID Title Journal Year
11959913 Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide

Ouellet, H, Ouellet, Y, Richard, C, Labarre, M, Wittenberg, B, Wittenberg, J, Guertin, M

Proc Natl Acad Sci U S A 2002
12207698 Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis haemoglobin, HbN in Escherichia coli

Pathania, R, Navani, NK, Gardner, AM, Gardner, PR, Dikshit, KL

Mol Microbiol 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
nitric oxide dioxygenase activity of GlbN:Heme dimer [cytosol]
Physical Entity
GlbN:Heme dimer [cytosol]
Activity
nitric oxide dioxygenase activity (0008941)
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)