Nitric oxide is oxidized to nitrate

Stable Identifier
R-HSA-1222723
Type
Reaction
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Heme proteins, especially the truncated globin GlbN in Mtb possess oxygen-dependent nitric oxide dioxygenase activity, where the heme that is oxidized to ferriheme in the process will need to be reduced in a second step to activate the protein again. The responsible heme protein reductase is unknown (Ouellet et al. 2002, Pathania et al. 2002).

Literature References
PubMed ID Title Journal Year
12207698 Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis haemoglobin, HbN in Escherichia coli

Dikshit, KL, Pathania, R, Gardner, AM, Navani, NK, Gardner, PR

Mol Microbiol 2002
11959913 Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide

Richard, C, Ouellet, H, Wittenberg, B, Labarre, M, Wittenberg, J, Guertin, M, Ouellet, Y

Proc Natl Acad Sci U S A 2002
Participants
Participates
Catalyst Activity

nitric oxide dioxygenase activity of GlbN:Heme dimer [cytosol]

Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created
Cite Us!