Nitric oxide is oxidized to nitrate

Stable Identifier
R-HSA-1222723
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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Nitric oxide is oxidized to nitrate
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Heme proteins, especially the truncated globin GlbN in Mtb possess oxygen-dependent nitric oxide dioxygenase activity, where the heme that is oxidized to ferriheme in the process will need to be reduced in a second step to activate the protein again. The responsible heme protein reductase is unknown (Ouellet et al. 2002, Pathania et al. 2002).
Literature References
PubMed ID Title Journal Year
12207698 Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis haemoglobin, HbN in Escherichia coli

Pathania, R, Navani, NK, Gardner, AM, Gardner, PR, Dikshit, KL

Mol Microbiol 2002
11959913 Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide

Ouellet, H, Ouellet, Y, Richard, C, Labarre, M, Wittenberg, B, Wittenberg, J, Guertin, M

Proc Natl Acad Sci U S A 2002
Participants
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Output
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as an event of
Catalyst Activity

nitric oxide dioxygenase NAD(P)H activity of GlbN:Heme dimer [cytosol]

Physical Entity
GlbN:Heme dimer [cytosol] (Mycobacterium tuberculosis)
Activity
nitric oxide dioxygenase NAD(P)H activity (GO:0008941)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Mondo
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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