Heme proteins, especially the truncated globin GlbN in Mtb possess oxygen-dependent nitric oxide dioxygenase activity, where the heme that is oxidized to ferriheme in the process will need to be reduced in a second step to activate the protein again. The responsible heme protein reductase is unknown (Ouellet et al. 2002, Pathania et al. 2002).
Dikshit, KL, Pathania, R, Gardner, AM, Navani, NK, Gardner, PR
Richard, C, Ouellet, H, Wittenberg, B, Labarre, M, Wittenberg, J, Guertin, M, Ouellet, Y
nitric oxide dioxygenase activity of GlbN:Heme dimer [cytosol]
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