Reactome | KatG reduces H2O2

KatG reduces H2O2

Stable Identifier

R-HSA-1222704

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Mycobacterium tuberculosis

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Mycobacterium tuberculosis (Homo sapiens)
      - Latent infection - Other responses of Mtb to phagocytosis (Homo sapiens)
        
        Tolerance of reactive oxygen produced by macrophages (Homo sapiens)
        
        KatG reduces H2O2 (Homo sapiens)

General

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Another important antioxidant activity is the KatG catalase/peroxidase which also activates the anti-tuberculosis drug isoniazid (Nagy et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9395452	Purification and characterization of recombinant catalase-peroxidase, which confers isoniazid sensitivity in Mycobacterium tuberculosis Cass, AE, Brown, KA, Nagy, JM	J Biol Chem	1997

Participants

Input

x 2 H2O2 [cytosol]

Output

x 2 H2O [cytosol]
O2 [cytosol]

Participates

as an event of

Tolerance of reactive oxygen produced by macrophages (Homo sapiens)

Catalyst Activity

catalase activity of KatG dimer [cytosol]

Physical Entity

KatG dimer [cytosol] (Mycobacterium tuberculosis)

Activity

catalase activity (GO:0004096)

Disease

Name	Identifier	Synonyms
tuberculosis	DOID:399	tuberculous abscess, Tuberculoma (finding), tuberculoma

Cross References

Rhea

20310

Authored

Stephan, R (2011-01-10)

Reviewed

Warner, D (2012-04-30)

Created

Jassal, B (2011-02-28)

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