DlaT reactivates AhpD

Stable Identifier
R-HSA-1222690
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
DlaT reactivates AhpD
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Peroxiredoxin AhpC gets its reducing equivalents through a cascade of proteins via AhpD, a disulfide reductase, DlaT, a lipoylated disulfide reductase, and, finally, from lpdC, the NADH-dependent dihydrolipoyl reductase. The latter two are also part of the pyruvate dehydrogenase complex (Venugopal et al. 2011).
Literature References
PubMed ID Title Journal Year
11799204 Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein

Bryk, R, Tempst, P, Nathan, C, Lima, CD, Erdjument-Bromage, H

Science 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

disulfide oxidoreductase activity of DlaT [cytosol]

Physical Entity
DlaT [cytosol] (Mycobacterium tuberculosis)
Activity
disulfide oxidoreductase activity (GO:0015036)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
Cite Us!