Loaded mycobactin gets imported

Stable Identifier
R-HSA-1222597
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
plasma membrane, cell wall, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Loaded mycobactin gets imported
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The ABC-type transporter IrtA, probably complexed with IrtB and ViuB (Rv2895c), specifically transports iron-loaded mycobactin into the cytosol (Ryndak et al. 2009).

Literature References
PubMed ID Title Journal Year
19948799 The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain

Ryndak, MB, Wang, S, Smith, I, Rodriguez, GM

J Bacteriol 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
siderophore transmembrane transporter activity of IrtAB:Rv2895c [plasma membrane]
Physical Entity
IrtAB:Rv2895c [plasma membrane]
Activity
siderophore transmembrane transporter activity (0015343)
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)