Loaded mycobactin gets imported

Stable Identifier
R-HSA-1222597
Type
Reaction
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
plasma membrane, cell wall, cytosol
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Loaded mycobactin gets imported
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The ABC-type transporter IrtA, probably complexed with IrtB and ViuB (Rv2895c), specifically transports iron-loaded mycobactin into the cytosol (Ryndak et al. 2009).

Literature References
PubMed ID Title Journal Year
19948799 The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain

Smith, I, Ryndak, MB, Rodriguez, GM, Wang, S

J Bacteriol 2010
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Output
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Catalyst Activity

siderophore transmembrane transporter activity of IrtAB:Rv2895c [plasma membrane]

Physical Entity
IrtAB:Rv2895c [plasma membrane] (Mycobacterium tuberculosis)
Activity
siderophore transmembrane transporter activity (GO:0015343)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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