MscR reduces nitrosomycothiol to ammonia

Stable Identifier
R-HSA-1222583
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
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MscR is an alcohol dehydrogenase that can probably reduce nitrosomycothiol with the help of NADH/H+ reducing equivalents to the sulfinamide which then presumably decomposes to the thione and ammonia (Vogt et al. 2003).

Literature References
PubMed ID Title Journal Year
12809551 The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase

Vogt, RN, Steenkamp, DJ, Zheng, R, Blanchard, JS

Biochem J 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor of MscR:Zn2+ [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created