MscR reduces nitrosomycothiol to ammonia

Stable Identifier
R-HSA-1222583
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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MscR reduces nitrosomycothiol to ammonia
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MscR is an alcohol dehydrogenase that can probably reduce nitrosomycothiol with the help of NADH/H+ reducing equivalents to the sulfinamide which then presumably decomposes to the thione and ammonia (Vogt et al. 2003).

Literature References
PubMed ID Title Journal Year
12809551 The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase

Vogt, RN, Steenkamp, DJ, Blanchard, JS, Zheng, R

Biochem J 2003
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Output
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as an event of
Catalyst Activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor of MscR:Zn2+ [cytosol]

Physical Entity
MscR:Zn2+ [cytosol] (Mycobacterium tuberculosis)
Activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (GO:0016620)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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