Reactome | AhpC reduces peroxidated lipids

AhpC reduces peroxidated lipids

Stable Identifier

R-HSA-1222526

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Mycobacterium tuberculosis

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Mycobacterium tuberculosis (Homo sapiens)
      - Latent infection - Other responses of Mtb to phagocytosis (Homo sapiens)
        
        Tolerance of reactive oxygen produced by macrophages (Homo sapiens)
        
        AhpC reduces peroxidated lipids (Homo sapiens)

General

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Reduction of peroxidated lipids depends on reduced AhpC, the only alkyl hydoperoxidase in Mtb (Chauhan & Mande 2001).

Literature References

PubMed ID	Title	Journal	Year
11171096	Characterization of the Mycobacterium tuberculosis H37Rv alkyl hydroperoxidase AhpC points to the importance of ionic interactions in oligomerization and activity Chauhan, R, Mande, SC	Biochem J	2001

Participants

Input

Output

Participates

as an event of

Tolerance of reactive oxygen produced by macrophages (Homo sapiens)

Catalyst Activity

NADH-dependent peroxiredoxin activity of AhpC hexamer [cytosol]

Physical Entity

AhpC hexamer [cytosol] (Mycobacterium tuberculosis)

Activity

NADH-dependent peroxiredoxin activity (GO:0102039)

Disease

Name	Identifier	Synonyms
tuberculosis	DOID:399	tuberculous abscess, Tuberculoma (finding), tuberculoma

Authored

Stephan, R (2011-01-10)

Reviewed

Warner, D (2012-04-30)

Created

Jassal, B (2011-02-28)

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