Intraphagosomal pH is lowered to 5 by V-ATPase

Stable Identifier
R-HSA-1222516
Type
Reaction [transition]
Species
Homo sapiens
Compartment
phagocytic vesicle membrane, cytosol, phagocytic vesicle lumen
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Intraphagosomal pH is lowered to 5 by V-ATPase
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The function of V-type proton pumping ATPases is basically the same as that of F-type ATPases, except that V-ATPases cannot synthesize ATP from the proton motive force, the reverse reaction of pumping. When pumping, ATP hydrolysis drives a 120 degree rotation of the rotor which leads to movement of three protons into the phagosome (Adachi et al. 2007).

Literature References
PubMed ID Title Journal Year
17662945 Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation

Adachi, K, Oiwa, K, Nishizaka, T, Furuike, S, Noji, H, Itoh, H, Yoshida, M, Kinosita K, Jr

Cell 2007
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
phagosome acidification (0090383)
Catalyst Activity
Catalyst Activity
Title
proton transmembrane transporter activity of V-ATPase [phagocytic vesicle membrane]
Physical Entity
V-ATPase [phagocytic vesicle membrane]
Activity
proton transmembrane transporter activity (0015078)
Orthologous Events
Intraphagosomal pH is lowered to 5 by V-ATPase (Bos taurus)
Intraphagosomal pH is lowered to 5 by V-ATPase (Caenorhabditis elegans)
Intraphagosomal pH is lowered to 5 by V-ATPase (Canis familiaris)
Intraphagosomal pH is lowered to 5 by V-ATPase (Danio rerio)
Intraphagosomal pH is lowered to 5 by V-ATPase (Dictyostelium discoideum)
Intraphagosomal pH is lowered to 5 by V-ATPase (Drosophila melanogaster)
Intraphagosomal pH is lowered to 5 by V-ATPase (Gallus gallus)
Intraphagosomal pH is lowered to 5 by V-ATPase (Mus musculus)
Intraphagosomal pH is lowered to 5 by V-ATPase (Plasmodium falciparum)
Intraphagosomal pH is lowered to 5 by V-ATPase (Rattus norvegicus)
Intraphagosomal pH is lowered to 5 by V-ATPase (Saccharomyces cerevisiae)
Intraphagosomal pH is lowered to 5 by V-ATPase (Schizosaccharomyces pombe)
Intraphagosomal pH is lowered to 5 by V-ATPase (Sus scrofa)
Intraphagosomal pH is lowered to 5 by V-ATPase (Xenopus tropicalis)
Cross References
Rhea
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)