Nitric oxide oxidizes to nitrosyl ion

Stable Identifier
R-HSA-1222512
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Nitric oxide oxidizes to nitrosyl ion
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Production of nitrosyl ion from nitric oxide is much faster when catalyzed by metal ions than via NO2 or N2O3. An alternative mechanism is by reaction with superoxide which is less probable in macrophages because they downregulate pathways leading to superoxide when NO is produced (Kharitonov et al. 1995, Clancy et al. 1994).

Literature References
PubMed ID Title Journal Year
8170969 Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary

Clancy, RM, Levartovsky, D, Leszczynska-Piziak, J, Yegudin, J, Abramson, SB

Proc Natl Acad Sci U S A 1994
7499306 Kinetics of nitrosation of thiols by nitric oxide in the presence of oxygen

Kharitonov, VG, Sundquist, AR, Sharma, VS

J Biol Chem 1995
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Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)