Production of nitrosyl ion from nitric oxide is much faster when catalyzed by metal ions than via NO2 or N2O3. An alternative mechanism is by reaction with superoxide which is less probable in macrophages because they downregulate pathways leading to superoxide when NO is produced (Kharitonov et al. 1995, Clancy et al. 1994).
Clancy, RM, Levartovsky, D, Leszczynska-Piziak, J, Yegudin, J, Abramson, SB
Kharitonov, VG, Sundquist, AR, Sharma, VS
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