TrxB reactivates TrxA

Stable Identifier
R-HSA-1222485
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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TrxB reactivates TrxA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TrxB is an NADPH-dependent thioredoxin reductase that reactivates TrxA (Jaeger et al. 2006).
Literature References
PubMed ID Title Journal Year
14871480 Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis

Singh, M, Flohé, L, Radi, R, Budde, H, Jaeger, T, Trujillo, M, Menge, U

Arch Biochem Biophys 2004
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Output
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Catalyst Activity

thioredoxin-disulfide reductase (NADPH) activity of TrxB dimer [cytosol]

Physical Entity
TrxB dimer [cytosol] (Mycobacterium tuberculosis)
Activity
thioredoxin-disulfide reductase (NADPH) activity (GO:0004791)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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