Peroxynitrite is reduced to nitrite by AhpC

Stable Identifier
R-HSA-1222431
Type
Reaction
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
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Peroxynitrite is reduced to nitrite by AhpC
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

AhpC is an unusual peroxiredoxin - it has three cysteine residues that participate in the reduction of toxic peroxynitrite to nitrite. In a second step, another thioredoxin or the reductase chain AhpD/DlaT/Lpd is needed for reactivation (Guimaraes et al. 2005).

Literature References
PubMed ID Title Journal Year
15886207 Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress

Cole, ST, Guimarães, BG, Brosch, R, Alzari, PM, Shepard, W, Souchon, H, Honoré, N, Saint-Joanis, B

J Biol Chem 2005
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Catalyst Activity

peroxiredoxin activity of AhpC hexamer [cytosol]

Physical Entity
AhpC hexamer [cytosol] (Mycobacterium tuberculosis)
Activity
peroxiredoxin activity (GO:0051920)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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