Peroxynitrite is reduced to nitrite by AhpC

Stable Identifier
R-HSA-1222431
Type
Reaction
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
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AhpC is an unusual peroxiredoxin - it has three cysteine residues that participate in the reduction of toxic peroxynitrite to nitrite. In a second step, another thioredoxin or the reductase chain AhpD/DlaT/Lpd is needed for reactivation (Guimaraes et al. 2005).

Literature References
PubMed ID Title Journal Year
15886207 Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress

Cole, ST, GuimarĂ£es, BG, Brosch, R, Alzari, PM, Shepard, W, Souchon, H, HonorĂ©, N, Saint-Joanis, B

J Biol Chem 2005
Participants
Participates
Catalyst Activity

peroxiredoxin activity of AhpC hexamer [cytosol]

Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
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