Peroxynitrite is reduced to nitrite by AhpC

Stable Identifier
R-HSA-1222431
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Peroxynitrite is reduced to nitrite by AhpC
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

AhpC is an unusual peroxiredoxin - it has three cysteine residues that participate in the reduction of toxic peroxynitrite to nitrite. In a second step, another thioredoxin or the reductase chain AhpD/DlaT/Lpd is needed for reactivation (Guimaraes et al. 2005).

Literature References
PubMed ID Title Journal Year
15886207 Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress

Guimarães, BG, Souchon, H, Honoré, N, Saint-Joanis, B, Brosch, R, Shepard, W, Cole, ST, Alzari, PM

J Biol Chem 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
peroxiredoxin activity of AhpC hexamer [cytosol]
Physical Entity
AhpC hexamer [cytosol]
Activity
peroxiredoxin activity (0051920)
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
Cite Us!