Tolerance of reactive oxygen produced by macrophages

Stable Identifier
R-HSA-1222387
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
ReviewStatus
5/5
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Tolerance of reactive oxygen produced by macrophages
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The expression of AhpC in Mycobacteria does not correlate with virulence; instead, the most important parts of the antioxidant system in Mtb appear to be the lipid cell wall, the enzymes SodB/SodC (superoxide dismutases), and the catalase/peroxidase KatG. Together with the enzyme system that acts on nitrosative stress and the sequestration of iron, these appear to be critical in defending against the macrophage's production of ROS/RNS, and enable the bacterium to exist in the phagosome for extended periods (Zahrt & Deretic 2002).
Literature References
PubMed ID Title Journal Year
11970850 Reactive nitrogen and oxygen intermediates and bacterial defenses: unusual adaptations in Mycobacterium tuberculosis

Zahrt, TC, Deretic, V

Antioxid Redox Signal 2002
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Event Information
Go Biological Process
symbiont defense to host-produced reactive oxygen species (0052164)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
BioModels Database
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
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