MsrA and MsrB are enzymes that can both reduce the S- and R-stereoisomers of (peptidyl-) methionine sulfoxide. The exact nature of the accompanying thioredoxin is not settled, but it is predicted to be TrxA. The whole methionine-MsrA/B-thioredoxin-and-reductase system is an important part of NO detoxification in Mtb (St John et al. 2001, Lee et al. 2009).
Jacobs WR, Jr, St John, G, Wellner, D, de Carvalho, LP, Gold, B, Lee, WL, Darby, C, Nathan, C, Jiang, X, Brot, N
St John, G, Tempst, P, Nathan, C, Ruan, J, Weissbach, H, Erdjument-Bromage, H, Brot, N
peptide-methionine (S)-S-oxide reductase activity of MsrA/B [cytosol]
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