MsrA/B reduces peptide-methionine S/R-sulfoxides

Stable Identifier
R-HSA-1222363
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MsrA/B reduces peptide-methionine S/R-sulfoxides
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MsrA and MsrB are enzymes that can both reduce the S- and R-stereoisomers of (peptidyl-) methionine sulfoxide. The exact nature of the accompanying thioredoxin is not settled, but it is predicted to be TrxA. The whole methionine-MsrA/B-thioredoxin-and-reductase system is an important part of NO detoxification in Mtb (St John et al. 2001, Lee et al. 2009).

Literature References
PubMed ID Title Journal Year
11481433 Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates

St John, G, Brot, N, Ruan, J, Erdjument-Bromage, H, Tempst, P, Weissbach, H, Nathan, C

Proc Natl Acad Sci U S A 2001
19040639 Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite

Lee, WL, Gold, B, Darby, C, Brot, N, Jiang, X, de Carvalho, LP, Wellner, D, St John, G, Jacobs WR, Jr, Nathan, C

Mol Microbiol 2009
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
peptide-methionine (S)-S-oxide reductase activity of MsrA/B [cytosol]
Physical Entity
MsrA/B [cytosol]
Activity
peptide-methionine (S)-S-oxide reductase activity (0008113)
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Cross References
Target Pathogen
Authored
Stephan, R  (2011-01-10)
Reviewed
Warner, D  (2012-04-30)
Created
Jassal, B  (2011-02-28)
Cite Us!