MsrA/B reduces peptide-methionine S/R-sulfoxides

Stable Identifier
R-HSA-1222363
Type
Reaction
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
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MsrA and MsrB are enzymes that can both reduce the S- and R-stereoisomers of (peptidyl-) methionine sulfoxide. The exact nature of the accompanying thioredoxin is not settled, but it is predicted to be TrxA. The whole methionine-MsrA/B-thioredoxin-and-reductase system is an important part of NO detoxification in Mtb (St John et al. 2001, Lee et al. 2009).

Literature References
PubMed ID Title Journal Year
19040639 Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite

Jacobs WR, Jr, St John, G, Wellner, D, de Carvalho, LP, Gold, B, Lee, WL, Darby, C, Nathan, C, Jiang, X, Brot, N

Mol Microbiol 2009
11481433 Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates

St John, G, Tempst, P, Nathan, C, Ruan, J, Weissbach, H, Erdjument-Bromage, H, Brot, N

Proc Natl Acad Sci U S A 2001
Participants
Participates
Catalyst Activity

peptide-methionine (S)-S-oxide reductase activity of MsrA/B [cytosol]

Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
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