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EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane]
Stable Identifier
R-HSA-1220580
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
Binding of EGF to ligand-responsive EGFR mutants (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF-induced dimerization of ligand-responsive EGFR mutants (Homo sapiens)
EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants (Homo sapiens)
Active dimers of ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Sensitive ligand-responsive EGFR mutants:Non-covalent EGFR TKIs [plasma membrane] (Homo sapiens)
Active dimers of ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)
Active dimers of ligand-responsive EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants dimer [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Participants
components
CDC37 [cytosol]
(Homo sapiens)
EGF [extracellular region]
(Homo sapiens)
HSP90 [cytosol]
(Homo sapiens)
Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane]
(Homo sapiens)
Participates
as a component of
Dimers of EGF:Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
as a member of
EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
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