HSP90 is inactivated by binding to benzaquinoid ansamycins

Stable Identifier
R-HSA-1218824
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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HSP90 is inactivated by binding to benzaquinoid ansamycins
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Benzoquinoid ansamycins (geldanamycin, herbimycin, and geldanamycin derivatives 17-AAG, 17-DMAG and IPI-504) are antitumor antibiotics that inactivate HSP90 by binding to its substrate-binding pocket.

Literature References
PubMed ID Title Journal Year
9108479 Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

Pavletich, NP, Hartl, FU, Schneider, C, Russo, AA, Stebbins, CE, Rosen, N

Cell 1997
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Greulich, H  (2011-11-15)
Savas, S  (2011-11-15)
Created
Orlic-Milacic, M  (2011-02-18)
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