HSP90 is inactivated by binding to benzaquinoid ansamycins

Stable Identifier
R-HSA-1218824
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Benzoquinoid ansamycins (geldanamycin, herbimycin, and geldanamycin derivatives 17-AAG, 17-DMAG and IPI-504) are antitumor antibiotics that inactivate HSP90 by binding to its substrate-binding pocket.

Literature References
PubMed ID Title Journal Year
9108479 Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

Stebbins, CE, Russo, AA, Schneider, C, Rosen, N, Hartl, FU, Pavletich, NP

Cell 1997
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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