Expression of GLUT4

Stable Identifier
R-HSA-1183032
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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Expression of GLUT4
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The GLUT4 (SLC2A4) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. As inferred from mouse cells, C/EBPalpha (CEBPA) binds the promoter of the GLUT4 (SLC2A4) gene and activates transcription. As inferred from mouse cells, PPARG:RXRA in the absence of fatty acid ligand binds the promoter of the GLUT4 (SLC2A4) gene and represses expression. After activation of PPARG:RXRA by fatty acid ligand the repression is relieved.
Literature References
PubMed ID Title Journal Year
8325954 Insulin-responsive human adipocytes express two glucose transporter isoforms and target them to different vesicles

Wilkinson, W, Pilch, PF, Olefsky, JM, Hueckstaedt, TP, Garvey, WT, Ciaraldi, TP

J Clin Endocrinol Metab 1993
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PPARG:RXRA:Corepressor Complex [nucleoplasm] (Homo sapiens)
Positively by
Regulator
CEBPA [nucleoplasm] (Homo sapiens)
Authored
May, B  (2011-02-08)
Reviewed
Sethi, JK  (2011-02-10)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2011-02-10)
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