Expression of Leptin

Stable Identifier
Reaction [omitted]
Homo sapiens
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The Ob gene encoding leptin is transcribed to yield mRNA and translated to yield protein. Expression of leptin is positively regulated by C/EBPalpha (CEBPA, Miller et al. 1996, Melzner et al. 2002) and negatively regulated by PPARG in adipocytes (De Vos et al. 1996). C/EBPalpha (CEBPA) binds the promoter of the Ob gene encoding leptin and activates transcription. PPARG together with an agonist, the thiazolidinedione BRL49653, repress expression of the Ob (leptin) gene.
Literature References
PubMed ID Title Journal Year
8770873 Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma

Miller, SG, Lefebvre, AM, De Vos, P, Wong, K, Guerre-Millo, M, Briggs, MR, Staels, B, Hamann, LG, Saladin, R, Auwerx, J

J Clin Invest 1996
12213831 Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter

Melzner, I, Bruderlein, S, Scott, V, Hasel, C, Fischer, P, Moller, P, Dorsch, K, Wabitsch, M

J Biol Chem 2002
8643605 The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression

Miller, SG, De Vos, P, Wong, K, Guerre-Millo, M, Briggs, MR, Hermann, T, Staels, B, Auwerx, J

Proc Natl Acad Sci U S A 1996
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