Reactome | Expression of Leptin

Expression of Leptin

Stable Identifier

R-HSA-1183003

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, extracellular region

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The Ob gene encoding leptin is transcribed to yield mRNA and translated to yield protein. Expression of leptin is positively regulated by C/EBPalpha (CEBPA, Miller et al. 1996, Melzner et al. 2002) and negatively regulated by PPARG in adipocytes (De Vos et al. 1996).

C/EBPalpha (CEBPA) binds the promoter of the Ob gene encoding leptin and activates transcription.

PPARG together with an agonist, the thiazolidinedione BRL49653, repress expression of the Ob (leptin) gene.

Literature References

PubMed ID	Title	Journal	Year
8770873	Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma Miller, SG, Lefebvre, AM, De Vos, P, Wong, K, Guerre-Millo, M, Briggs, MR, Staels, B, Hamann, LG, Saladin, R, Auwerx, J	J Clin Invest	1996
12213831	Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter Melzner, I, Bruderlein, S, Scott, V, Hasel, C, Fischer, P, Moller, P, Dorsch, K, Wabitsch, M	J Biol Chem	2002
8643605	The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression Miller, SG, De Vos, P, Wong, K, Guerre-Millo, M, Briggs, MR, Hermann, T, Staels, B, Auwerx, J	Proc Natl Acad Sci U S A	1996