The Ob gene encoding leptin is transcribed to yield mRNA and translated to yield protein. Expression of leptin is positively regulated by C/EBPalpha (CEBPA, Miller et al. 1996, Melzner et al. 2002) and negatively regulated by PPARG in adipocytes (De Vos et al. 1996).
C/EBPalpha (CEBPA) binds the promoter of the Ob gene encoding leptin and activates transcription.
PPARG together with an agonist, the thiazolidinedione BRL49653, repress expression of the Ob (leptin) gene.
Miller, SG, Lefebvre, AM, De Vos, P, Wong, K, Guerre-Millo, M, Briggs, MR, Staels, B, Hamann, LG, Saladin, R, Auwerx, J
Melzner, I, Bruderlein, S, Scott, V, Hasel, C, Fischer, P, Moller, P, Dorsch, K, Wabitsch, M
Miller, SG, De Vos, P, Wong, K, Guerre-Millo, M, Briggs, MR, Hermann, T, Staels, B, Auwerx, J
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