Expression of Leptin

Stable Identifier
R-HSA-1183003
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
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Expression of Leptin
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The Ob gene encoding leptin is transcribed to yield mRNA and translated to yield protein. Expression of leptin is positively regulated by C/EBPalpha (CEBPA, Miller et al. 1996, Melzner et al. 2002) and negatively regulated by PPARG in adipocytes (De Vos et al. 1996).

Literature References
PubMed ID Title Journal Year
12213831 Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter

Melzner, I, Scott, V, Dorsch, K, Fischer, P, Wabitsch, M, Bruderlein, S, Hasel, C, Moller, P

J Biol Chem 2002
8770873 Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma

De Vos, P, Lefebvre, AM, Miller, SG, Guerre-Millo, M, Wong, K, Saladin, R, Hamann, LG, Staels, B, Briggs, MR, Auwerx, J

J Clin Invest 1996
8643605 The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression

Miller, SG, De Vos, P, Guerre-Millo, M, Wong, K, Hermann, T, Staels, B, Briggs, MR, Auwerx, J

Proc Natl Acad Sci U S A 1996
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Summation

PPARG together with an agonist, the thiazolidinedione BRL49653, repress expression of the Ob (leptin) gene.

Positively by
Regulator
CEBPA [nucleoplasm] (Homo sapiens)
Summation

C/EBPalpha (CEBPA) binds the promoter of the Ob gene encoding leptin and activates transcription.

Authored
May, B  (2011-02-08)
Reviewed
D'Eustachio, P  (2009-05-27)
Sethi, JK  (2011-02-10)
Created
May, B  (2011-02-10)
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