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What is Reactome ?
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Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane]
Stable Identifier
R-HSA-1182982
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex (Homo sapiens)
Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs [plasma membrane] (Homo sapiens)
Participants
members
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(Homo sapiens)
p-6Y-EGFR L858R;T790M [plasma membrane]
(Homo sapiens)
candidates
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(Homo sapiens)
p-6Y-EGFR N771_H773dup [plasma membrane]
(Homo sapiens)
p-6Y-EGFR A767_V769dup [plasma membrane]
(Homo sapiens)
p-6Y-EGFR K739_I744dup [plasma membrane]
(Homo sapiens)
Participates
as a component of
EGF:Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Ligand-responsive p-6Y-EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
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