CERBERUS binds NODAL

Stable Identifier
R-HSA-1181354
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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As inferred from Xenopus (Piccolo 1999) and as observed in human cells (Aykul et al. 2015) CERBERUS binds NODAL and inhibits NODAL signaling. CERBERUS and NODAL are believed to bind as dimer to form a tetrameric complex (Aykul et al. 2015)

Literature References
PubMed ID Title Journal Year
10067895 The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

Piccolo, S, Agius, E, Leyns, L, Bhattacharyya, S, Grunz, H, Bouwmeester, T, De Robertis, EM

Nature 1999
25603319 Human Cerberus prevents nodal-receptor binding, inhibits nodal signaling, and suppresses nodal-mediated phenotypes

Aykul, S, Ni, W, Mutatu, W, Martinez-Hackert, E

PLoS ONE 2015
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