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Reactome Pathway Database

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LEFTY1,2

Stable Identifier
R-HSA-1181332
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
LEFTY1 and LEFTY2
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
    • Signaling by NODAL (Homo sapiens)
      • Regulation of signaling by NODAL (Homo sapiens)
        • LEFTY binds NODAL (Homo sapiens)
          • LEFTY1,2 [extracellular region] (Homo sapiens)
          • LEFTY1,2:NODAL [extracellular region] (Homo sapiens)
            • LEFTY1,2 [extracellular region] (Homo sapiens)
        • LEFTY binds the EGF-CFC coreceptor in the NODAL receptor (Homo sapiens)
          • LEFTY1,2 [extracellular region] (Homo sapiens)
          • LEFTY1,2:NODAL Receptor [plasma membrane] (Homo sapiens)
            • LEFTY1,2 [extracellular region] (Homo sapiens)
      • The NODAL Receptor binds NODAL ligands (Homo sapiens)
        • LEFTY1,2 [extracellular region] (Homo sapiens)
Participants
members
  • LEFTY1 [extracellular region] (Homo sapiens)
  • LEFTY2(22-366) [extracellular region] (Homo sapiens)
Participant Of
input
  • LEFTY binds NODAL
  • LEFTY binds the EGF-CFC coreceptor in the NODAL receptor
hasComponent
  • LEFTY1,2:NODAL [extracellular region]
  • LEFTY1,2:NODAL Receptor [plasma membrane]
This entity regulates
Negative Regulation
  • Negative regulation by 'LEFTY1,2 [extracellular region]'
  • Negative regulation by 'LEFTY1,2 [extracellular region]'
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