The NODAL Receptor binds NODAL ligands

Stable Identifier
R-HSA-1181155
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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The NODAL Receptor binds NODAL ligands
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NODAL binds a receptor comprising a type I activin receptor (ACVR1B or ACVR1C), a type II activin receptor (ACVR2 or ACVR2B), and a EGF-CFC coreceptor (CRIPTO or CRYPTIC). Though NODAL is able to signal via the ACVR1C (ALK7) receptor (Reissman et al. 2001), experiments in mouse indicate NODAL signaling via ALK7 is dispensable during embryogenesis (Jornvall et al. 2004). CERBERUS (CER1) and probably DAND5 (CER2, inferred from mouse homologs) forms heterodimers with NODAL, preventing NODAL from activating the NODAL receptor. LEFTY1 and LEFTY2 bind the EGF-CFC coreceptor (CRIPTO or CRYPTIC) and prevent it from interacting with Activin type I and type II receptors, thereby interfering with the assembly of the NODAL receptor.
Literature References
PubMed ID Title Journal Year
21229555 Expression of nodal and nodal receptors in prostate stem cells and prostate cancer cells: Autocrine effects on cell proliferation and migration

Vo, BT, Khan, SA

Prostate 2011
21356369 Nodal Signals through Activin Receptor-Like Kinase 7 to Inhibit Trophoblast Migration and Invasion Implication in the Pathogenesis of Preeclampsia

Caniggia, I, Lye, S, Dunk, C, Peng, C, Munir, S, Nadeem, L, Baczyk, D, Fu, G

Am J Pathol 2011
15531507 Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7

Tsang, BK, Peng, C, Munir, S, Zhong, Y, Yang, BB, Xu, G

J Clin Endocrinol Metab 2004
15150278 Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells

Yang, B, Wu, Y, Peng, C, Lala, PK, Munir, S, Xu, G

J Biol Chem 2004
15485907 ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse

Jörnvall, H, Andersson, O, Reissmann, E, Mehrkash, M, Ibáñez, CF

Mol Cell Biol 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
CER1,2 [extracellular region] (Homo sapiens)
Regulator
LEFTY1,2 [extracellular region] (Homo sapiens)
Inferred From
The Nodal Receptor binds Nodal ligands (Mus musculus)
Authored
May, B  (2011-01-23)
Reviewed
Peng, C  (2011-08-25)
Created
May, B  (2011-01-28)
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