The NODAL Receptor binds NODAL ligands

Stable Identifier
Reaction [binding]
Homo sapiens
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NODAL binds a receptor comprising a type I activin receptor (ACVR1B or ACVR1C), a type II activin receptor (ACVR2 or ACVR2B), and a EGF-CFC coreceptor (CRIPTO or CRYPTIC). Though NODAL is able to signal via the ACVR1C (ALK7) receptor (Reissman et al. 2001), experiments in mouse indicate NODAL signaling via ALK7 is dispensable during embryogenesis (Jornvall et al. 2004).

Literature References
PubMed ID Title Journal Year
21356369 Nodal Signals through Activin Receptor-Like Kinase 7 to Inhibit Trophoblast Migration and Invasion Implication in the Pathogenesis of Preeclampsia

Nadeem, L, Munir, S, Fu, G, Dunk, C, Baczyk, D, Caniggia, I, Lye, S, Peng, C

Am J Pathol 2011
21229555 Expression of nodal and nodal receptors in prostate stem cells and prostate cancer cells: Autocrine effects on cell proliferation and migration

Vo, BT, Khan, SA

Prostate 2011
15531507 Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7

Xu, G, Zhong, Y, Munir, S, Yang, BB, Tsang, BK, Peng, C

J Clin Endocrinol Metab 2004
15150278 Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cells

Munir, S, Xu, G, Wu, Y, Yang, B, Lala, PK, Peng, C

J Biol Chem 2004
15485907 ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse

Jörnvall, H, Reissmann, E, Andersson, O, Mehrkash, M, Ibáñez, CF

Mol Cell Biol 2004
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