Reactome | Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B

Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B

Stable Identifier

R-HSA-1181153

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

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Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B

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Activin binds the Activin receptor composed of a type II receptor (ACVR2A/B) and a type I receptor, in this case ACVR1B (ALK4) (Attisano et al. 1996, Zhou et al. 2000). Activin appears to interact initially with the type II receptor component (Attisano et al. 1996). It is unclear if the type II and type I receptors are associated before binding Activin. Any of Activin A (INHBA:INHBA), Activin AB (INHBA:INHBB), and Activin B (INHBB:INHBB) can bind and signal via an activin receptor containing the ACVR1B (ALK4) type I receptor.

Literature References

PubMed ID	Title	Journal	Year
8196624	Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin Massague, J, Wrana, JL, Weis, FM, Carcamo, J, Wieser, R, Attisano, L, Ventura, F	Mol Cell Biol	1994
11117535	Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling Zhang, X, Klibanski, A, Zhou, Y, Sigai, DP, Danila, DC, Sun, H, Johnson, SR	Mol Endocrinol	2000
9032295	Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation Lebrun, JJ, Vale, WW	Mol Cell Biol	1997
8622651	Activation of signalling by the activin receptor complex Massague, J, Wrana, JL, Attisano, L, Montalvo, E	Mol Cell Biol	1996