Activin A/AB/B binds Activin Receptor ACVR2A/B:ACVR1B

Stable Identifier
R-HSA-1181153
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activin binds the Activin receptor composed of a type II receptor (ACVR2A/B) and a type I receptor, in this case ACVR1B (ALK4) (Attisano et al. 1996, Zhou et al. 2000). Activin appears to interact initially with the type II receptor component (Attisano et al. 1996). It is unclear if the type II and type I receptors are associated before binding Activin. Any of Activin A (INHBA:INHBA), Activin AB (INHBA:INHBB), and Activin B (INHBB:INHBB) can bind and signal via an activin receptor containing the ACVR1B (ALK4) type I receptor.

Literature References
PubMed ID Title Journal Year
11117535 Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling

Zhou, Y, Sun, H, Danila, DC, Johnson, SR, Sigai, DP, Zhang, X, Klibanski, A

Mol Endocrinol 2000
8196624 Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin

Carcamo, J, Weis, FM, Ventura, F, Wieser, R, Wrana, JL, Attisano, L, Massague, J

Mol Cell Biol 1994
9032295 Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation

Lebrun, JJ, Vale, WW

Mol Cell Biol 1997
8622651 Activation of signalling by the activin receptor complex

Attisano, L, Wrana, JL, Montalvo, E, Massague, J

Mol Cell Biol 1996
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created