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Cleavage of NODAL proprotein
Stable Identifier
R-HSA-1181152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Signaling by NODAL (Homo sapiens)
Cleavage of NODAL proprotein (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Either FURIN or PACE4 endoproteases cleave the 321 amino acid NODAL proprotein to yield the 110 amino acid NODAL mature protein. In cultured mouse cells the CRIPTO coreceptor at the plasma membrane recruits both NODAL proprotein and FURIN or PACE4 endoprotease.
Participants
Input
NODAL(27-347) dimer [extracellular region]
(Homo sapiens)
Output
NODAL dimer [extracellular region]
(Homo sapiens)
Participates
as an event of
Signaling by NODAL (Homo sapiens)
Catalyst Activity
serine-type endopeptidase activity of FURIN, PACE4 [extracellular region]
Physical Entity
FURIN, PACE4 [extracellular region]
(Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Cleavage of Nodal proprotein (Mus musculus)
Authored
May, B (2011-01-23)
Reviewed
Peng, C (2011-08-25)
Created
May, B (2011-01-28)
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