Cleavage of NODAL proprotein

Stable Identifier
R-HSA-1181152
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Cleavage of NODAL proprotein
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Either FURIN or PACE4 endoproteases cleave the 321 amino acid NODAL proprotein to yield the 110 amino acid NODAL mature protein. In cultured mouse cells the CRIPTO coreceptor at the plasma membrane recruits both NODAL proprotein and FURIN or PACE4 endoprotease.

Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of FURIN, PACE4 [extracellular region]

Physical Entity
FURIN, PACE4 [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Cleavage of Nodal proprotein (Mus musculus)
Authored
May, B  (2011-01-23)
Reviewed
Peng, C  (2011-08-25)
Created
May, B  (2011-01-28)
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