ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin

Stable Identifier
Reaction [transition]
Homo sapiens
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Upon binding Activin A (INHBA:INHBA), Activin AB (INHBA:INHBB), or Activin B (INHBB:INHBB), the type II component of the activin receptor (ACVR2A or ACVR2B) phosphorylates the type I component ACVR1B (ALK4) at multiple serine and threonine residues within the GS domain (Attisano et al. 1996, Willis et al. 1996, Willis and Mathews 1997, Zhou et al. 2000).
Literature References
PubMed ID Title Journal Year
15123686 An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors

Donaldson, C, Gray, PC, Vale, W, Choe, S, Fischer, WH, Harrison, CA

J Biol Chem 2004
9459292 Regulation of activin type I receptor function by phosphorylation of residues outside the GS domain

Willis, SA, Mathews, LS

FEBS Lett 1997
11117535 Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling

Zhang, X, Klibanski, A, Zhou, Y, Sigai, DP, Danila, DC, Sun, H, Johnson, SR

Mol Endocrinol 2000
8721982 Formation and activation by phosphorylation of activin receptor complexes

Willis, SA, Mathews, LS, Zimmerman, CM, Li, LI

Mol Endocrinol 1996
8622651 Activation of signalling by the activin receptor complex

Massague, J, Wrana, JL, Attisano, L, Montalvo, E

Mol Cell Biol 1996
Catalyst Activity

protein serine/threonine kinase activity of Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane]

Orthologous Events
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