ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin

Stable Identifier
R-HSA-1181149
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Upon binding Activin A (INHBA:INHBA), Activin AB (INHBA:INHBB), or Activin B (INHBB:INHBB), the type II component of the activin receptor (ACVR2A or ACVR2B) phosphorylates the type I component ACVR1B (ALK4) at multiple serine and threonine residues within the GS domain (Attisano et al. 1996, Willis et al. 1996, Willis and Mathews 1997, Zhou et al. 2000).

Literature References
PubMed ID Title Journal Year
9459292 Regulation of activin type I receptor function by phosphorylation of residues outside the GS domain

Willis, SA, Mathews, LS

FEBS Lett 1997
15123686 An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors

Harrison, CA, Gray, PC, Fischer, WH, Donaldson, C, Choe, S, Vale, W

J Biol Chem 2004
11117535 Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling

Zhou, Y, Sun, H, Danila, DC, Johnson, SR, Sigai, DP, Zhang, X, Klibanski, A

Mol Endocrinol 2000
8721982 Formation and activation by phosphorylation of activin receptor complexes

Willis, SA, Zimmerman, CM, Li, LI, Mathews, LS

Mol Endocrinol 1996
8622651 Activation of signalling by the activin receptor complex

Attisano, L, Wrana, JL, Montalvo, E, Massague, J

Mol Cell Biol 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed