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NODAL [extracellular region]
Stable Identifier
R-HSA-1181118
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Nodal homolog, NODAL_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Signaling by NODAL (Homo sapiens)
Cleavage of NODAL proprotein (Homo sapiens)
NODAL dimer [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
Phosphorylation of R-SMAD2/3 by NODAL receptor (Homo sapiens)
NODAL:p-NODAL Receptor [plasma membrane] (Homo sapiens)
NODAL dimer, NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL dimer [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
Regulation of signaling by NODAL (Homo sapiens)
CERBERUS binds NODAL (Homo sapiens)
CERBERUS:NODAL [extracellular region] (Homo sapiens)
NODAL dimer [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
NODAL dimer [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
LEFTY binds NODAL (Homo sapiens)
LEFTY1,2:NODAL [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
NODAL dimer [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
The NODAL Receptor binds NODAL ligands (Homo sapiens)
NODAL Ligand:NODAL Receptor [plasma membrane] (Homo sapiens)
NODAL dimer, NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL dimer [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
NODAL dimer, NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL dimer [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL (Homo sapiens)
NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
NODAL dimer, NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL dimer [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
NODAL:p-ACVR1B:ACVR2:EGF-CFC [plasma membrane] (Homo sapiens)
NODAL dimer, NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL dimer [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL (Homo sapiens)
NODAL:ACVR1C:ACVR2B:EGF-CFC [plasma membrane] (Homo sapiens)
NODAL dimer, NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL dimer [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
NODAL:p-ACVR1C:ACVR2B:EGF-CFC [plasma membrane] (Homo sapiens)
NODAL dimer, NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL dimer [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
NODAL:GDF1 [extracellular region] (Homo sapiens)
NODAL [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96S42 NODAL
Gene Names
NODAL
Chain
signal peptide:1-26, propeptide:27-237, chain:238-347
Reference Genes
BioGPS Gene:4838 NODAL
COSMIC (genes):NODAL NODAL
CTD Gene:4838 NODAL
dbSNP Gene:4838 NODAL
ENSEMBL:ENSG00000156574 NODAL
ENSEMBL_homo_sapiens_GENE:ENSG00000156574.10 NODAL
HGNC:7865 NODAL
KEGG Gene (Homo sapiens):4838 NODAL
Monarch:4838 NODAL
NCBI Gene:4838 NODAL
OMIM:601265 NODAL
UCSC:Q96S42 NODAL
Reference Transcript
RefSeq:NM_018055.4 NODAL
Other Identifiers
11731370_a_at
11731371_at
11731372_a_at
16715164
230916_PM_at
230916_at
237896_PM_at
237896_at
3293391
3293392
3293393
3293394
3293396
3293397
3293398
3293399
47797_at
4838
7934156
86358_at
A_23_P127322
A_33_P3299776
GE518874
GO:0000122
GO:0001701
GO:0001702
GO:0001707
GO:0001829
GO:0001831
GO:0001842
GO:0001889
GO:0001890
GO:0001892
GO:0001893
GO:0001944
GO:0001947
GO:0002085
GO:0003140
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0006351
GO:0006355
GO:0007155
GO:0007179
GO:0007281
GO:0007368
GO:0007369
GO:0007399
GO:0007420
GO:0007492
GO:0007507
GO:0007565
GO:0008083
GO:0008283
GO:0008284
GO:0009880
GO:0009948
GO:0009952
GO:0009966
GO:0010085
GO:0010470
GO:0010575
GO:0010721
GO:0016015
GO:0016477
GO:0019827
GO:0022409
GO:0022414
GO:0023052
GO:0030154
GO:0030324
GO:0032927
GO:0033505
GO:0035019
GO:0035050
GO:0035987
GO:0038092
GO:0042074
GO:0043280
GO:0045165
GO:0045596
GO:0045766
GO:0045944
GO:0048018
GO:0048327
GO:0048382
GO:0048546
GO:0048646
GO:0048701
GO:0048729
GO:0048856
GO:0048859
GO:0048870
GO:0050679
GO:0051091
GO:0055123
GO:0060136
GO:0060137
GO:0060391
GO:0060460
GO:0060766
GO:0060802
GO:0070374
GO:0070698
GO:0090009
GO:0098772
GO:1901164
GO:1901383
GO:2000036
GO:2000242
HMNXSV003002930
Hs.197600.0.A1_3p_at
Hs.65853.0.A1_3p_at
ILMN_1712537
PH_hs_0029901
TC10001365.hg
Participates
as a component of
LEFTY1,2:NODAL [extracellular region] (Homo sapiens)
NODAL dimer [extracellular region] (Homo sapiens)
NODAL:GDF1 [extracellular region] (Homo sapiens)
Other forms of this molecule
NODAL(27-347) [extracellular region]
Cross References
RefSeq
NP_060525.3
OpenTargets
ENSG00000156574
HPA
ENSG00000156574-NODAL
GeneCards
Q96S42
Ensembl
ENST00000287139
,
ENSP00000287139
,
ENSG00000156574
PRO
Q96S42
Pharos - Targets
Q96S42
Orphanet
20553
PDB
4N1D
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