ISGylation of IRF3

Stable Identifier
R-HSA-1169394
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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ISGylation of IRF3
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The transcription factor IRF3 is a target for ISGylation. Conjugation of ISG15 positively regulates IRF3 and thereby promotes induction of type I interferons. ISGylation of IRF3 prevents the binding of PIN1, a protein that promotes IRF3 ubiquitination and subsequent degradation.
Literature References
PubMed ID Title Journal Year
16914094 ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation

Lu, G, Reinert, JT, Pitha-Rowe, I, Okumura, A, Kellum, M, Knobeloch, KP, Hassel, B, Pitha-Rowe, PM

Cell Mol Biol (Noisy-le-grand) 2006
20308324 Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification

Shi, HX, Yang, K, Liu, X, Liu, XY, Wei, B, Shan, YF, Zhu, LH, Wang, C

Mol Cell Biol 2010
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as an event of
Catalyst Activity

ISG15 ligase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]

Physical Entity
ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
Activity
ISG15 ligase activity (GO:0061662)
Orthologous Events
ISGylation of IRF3 (Bos taurus)
ISGylation of IRF3 (Mus musculus)
ISGylation of IRF3 (Rattus norvegicus)
ISGylation of IRF3 (Sus scrofa)
Authored
Garapati, P V  (2011-01-18)
Reviewed
Zhang, DE  (2011-02-11)
D'Eustachio, P  (2025-10-21)
Created
Garapati, P V  (2011-01-18)
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