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ISGylated IRF3 [cytosol]
Stable Identifier
R-HSA-1169389
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 (Homo sapiens)
ISGylated IRF3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
ISGylation of IRF3 (Homo sapiens)
ISGylated IRF3 [cytosol] (Homo sapiens)
PIN1 mediated IRF3 degradation (Homo sapiens)
ISGylated IRF3 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
PIN1 mediated IRF3 degradation (Homo sapiens)
ISGylated IRF3 [cytosol] (Homo sapiens)
Participants
components
IRF3 [cytosol]
(Homo sapiens)
ISG15 [cytosol]
(Homo sapiens)
Participates
as an output of
ISGylation of IRF3 (Homo sapiens)
as an input of
SARS-CoV-2 nsp3 deISGylates ISGylated IRF3 (Homo sapiens)
This entity regulates
Negatively
PIN1 mediated IRF3 degradation
(Homo sapiens)
Inferred To
ISGylated IRF3 [cytosol]
(Bos taurus)
ISGylated IRF3 [cytosol]
(Mus musculus)
ISGylated IRF3 [cytosol]
(Rattus norvegicus)
ISGylated IRF3 [cytosol]
(Sus scrofa)
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