p-STAT5A/B dissociates from the Growth Hormone receptor

Stable Identifier
Reaction [dissociation]
Homo sapiens
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Deletion mutants have demonstrated that STAT dimerization can occur independently of the binding of 2 STAT molecules by a dimeric receptor. Although this does not exclude the possibility that STATs may dimerize while still associated with the receptor complex, dimerization is believed to occur following release of the phosphorylated monomers from the receptor complex and is typically represented in this manner (e.g. Turkson & Jove 2000).

Literature References
PubMed ID Title Journal Year
9030599 A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation

Behrmann, I, Janzen, C, Gerhartz, C, Schmitz-Van de Leur, H, Hermanns, H, Heesel, B, Graeve, L, Horn, F, Tavernier, J, Heinrich, PC

J Biol Chem 1997
Participant Of
Orthologous Events
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