Reactome | SCF-beta-TrCP ubiquitinylates IkB

SCF-beta-TrCP ubiquitinylates IkB

Stable Identifier

R-HSA-1168643

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

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SKP:Cul:F-box (SCF) complexes containing F-box factors Beta-TrCP1 (BTRCP, E3RSIkappaB) or beta-TrCP2 (BTRCP2, FBXW11, HOS) catalyze the polyubiquitination of IkappaB (Yaron et al. 1998, Fuchs et al. 1999, Suzuki et al. 1999, Tan et al. 1999, Winston et al. 1999, Wu and Ghosh 1999).

Literature References

PubMed ID	Title	Journal	Year
10230406	Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha Tan, P, Fuchs, SY, Chen, A, Wu, K, Gomez, C, Ronai, Z, Pan, ZQ	Mol Cell	1999
10514424	beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta Wu, C, Ghosh, S	J Biol Chem	1999
10066435	IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2 Suzuki, H, Chiba, T, Kobayashi, M, Takeuchi, M, Suzuki, T, Ichiyama, A, Ikenoue, T, Omata, M, Furuichi, K, Tanaka, K	Biochem Biophys Res Commun	1999
9990852	The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro Winston, JT, Strack, P, Beer-Romero, P, Chu, CY, Elledge, SJ, Harper, JW	Genes Dev	1999
10321728	HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin Fuchs, SY, Chen, A, Xiong, Y, Pan, ZQ, Ronai, Z	Oncogene	1999
9859996	Identification of the receptor component of the IkappaBalpha-ubiquitin ligase Yaron, A, Hatzubai, A, Davis, M, Lavon, I, Amit, S, Manning, AM, Andersen, JS, Mann, M, Mercurio, F, Ben-Neriah, Y	Nature	1998