SCF-beta-TrCP ubiquitinylates IkB

Stable Identifier
Reaction [omitted]
Homo sapiens
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SKP:Cul:F-box (SCF) complexes containing F-box factors Beta-TrCP1 (BTRCP, E3RSIkappaB) or beta-TrCP2 (BTRCP2, FBXW11, HOS) catalyze the polyubiquitination of IkappaB (Yaron et al. 1998, Fuchs et al. 1999, Suzuki et al. 1999, Tan et al. 1999, Winston et al. 1999, Wu and Ghosh 1999).
Literature References
PubMed ID Title Journal Year
10514424 beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta

Wu, C, Ghosh, S

J Biol Chem 1999
10230406 Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

Wu, K, Fuchs, SY, Ronai, Z, Chen, A, Pan, ZQ, Tan, P, Gomez, C

Mol Cell 1999
10066435 IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2

Tanaka, K, Chiba, T, Ichiyama, A, Omata, M, Ikenoue, T, Suzuki, H, Furuichi, K, Suzuki, T, Takeuchi, M, Kobayashi, M

Biochem Biophys Res Commun 1999
9990852 The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

Strack, P, Elledge, SJ, Beer-Romero, P, Chu, CY, Winston, JT, Harper, JW

Genes Dev 1999
10321728 HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin

Xiong, Y, Fuchs, SY, Ronai, Z, Chen, A, Pan, ZQ

Oncogene 1999
9859996 Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

Andersen, JS, Mann, M, Lavon, I, Manning, AM, Hatzubai, A, Amit, S, Mercurio, F, Yaron, A, Davis, M, Ben-Neriah, Y

Nature 1998
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