SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB

Stable Identifier
R-HSA-1168642
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB
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SKP:Cul:F-box (SCF) complexes containing F-box factors Beta-TrCP1 (BTRCP, E3RSIkappaB) or beta-TrCP2 (BTRCP2, FBXW11, HOS) bind IkappaB (Yaron et al. 1998, Fuchs et al. 1999, Suzuki et al. 1999, Tan et al. 1999, Winston et al. 1999, Wu and Ghosh 1999).

Literature References
PubMed ID Title Journal Year
10230406 Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

Wu, K, Fuchs, SY, Ronai, Z, Chen, A, Pan, ZQ, Tan, P, Gomez, C

Mol Cell 1999
10514424 beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta

Wu, C, Ghosh, S

J Biol Chem 1999
10066435 IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2

Tanaka, K, Chiba, T, Ichiyama, A, Omata, M, Ikenoue, T, Suzuki, H, Furuichi, K, Suzuki, T, Takeuchi, M, Kobayashi, M

Biochem Biophys Res Commun 1999
9990852 The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

Strack, P, Elledge, SJ, Beer-Romero, P, Chu, CY, Winston, JT, Harper, JW

Genes Dev 1999
10321728 HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin

Xiong, Y, Fuchs, SY, Ronai, Z, Chen, A, Pan, ZQ

Oncogene 1999
9859996 Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

Andersen, JS, Mann, M, Lavon, I, Manning, AM, Hatzubai, A, Amit, S, Mercurio, F, Yaron, A, Davis, M, Ben-Neriah, Y

Nature 1998
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Orthologous Events
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Bos taurus)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Danio rerio)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Drosophila melanogaster)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Gallus gallus)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Mus musculus)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Rattus norvegicus)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Xenopus tropicalis)
Authored
May, B  (2010-12-19)
Reviewed
Wienands, J  (2012-02-12)
Created
May, B  (2011-01-04)
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