p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP

Stable Identifier
R-HSA-1168636
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Activation of RAS by RasGRP1 and RasGRP3
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p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP
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RasGRP1 (Roose et al. 2007) and RasGRP3 (Ohba et al. 2000, Yamashita et al. 2000, Rebhun et al. 2000, Lorenzo et al. 2001) catalyze the exchange of GDP for GTP bound by RAS.

Literature References
PubMed ID Title Journal Year
10934204 Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction

Rebhun, JF, Castro, AF, Quilliam, LA

J Biol Chem 2000
17283063 Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes

Roose, JP, Mollenauer, M, Ho, M, Kurosaki, T, Weiss, A

Mol Cell Biol 2007
10777492 Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3

Ohba, Y, Mochizuki, N, Yamashita, S, Chan, AM, Schrader, JW, Hattori, S, Nagashima, K, Matsuda, M

J Biol Chem 2000
10835426 CalDAG-GEFIII activation of Ras, R-ras, and Rap1

Yamashita, S, Mochizuki, N, Ohba, Y, Tobiume, M, Okada, Y, Sawa, H, Nagashima, K, Matsuda, M

J Biol Chem 2000
11221888 Phorbol esters modulate the Ras exchange factor RasGRP3

Lorenzo, PS, Kung, JW, Bottorff, DA, Garfield, SH, Stone, JC, Blumberg, PM

Cancer Res 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of p-RASGRP1,3:DAG [plasma membrane]
Physical Entity
p-RASGRP1,3:DAG [plasma membrane]
Activity
guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Bos taurus)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Caenorhabditis elegans)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Canis familiaris)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Danio rerio)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Gallus gallus)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Mus musculus)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Rattus norvegicus)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Sus scrofa)
p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP (Xenopus tropicalis)
Authored
May, B  (2011-01-04)
Reviewed
Wienands, J  (2012-02-12)
Created
May, B  (2011-01-04)
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