p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP

Stable Identifier
Reaction [transition]
Homo sapiens
Activation of RAS by RasGRP1 and RasGRP3
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RasGRP1 (Roose et al. 2007) and RasGRP3 (Ohba et al. 2000, Yamashita et al. 2000, Rebhun et al. 2000, Lorenzo et al. 2001) catalyze the exchange of GDP for GTP bound by RAS.

Literature References
PubMed ID Title Journal Year
10934204 Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction

Rebhun, JF, Castro, AF, Quilliam, LA

J Biol Chem 2000
17283063 Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes

Roose, JP, Mollenauer, M, Ho, M, Kurosaki, T, Weiss, A

Mol Cell Biol 2007
10777492 Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3

Ohba, Y, Mochizuki, N, Yamashita, S, Chan, AM, Schrader, JW, Hattori, S, Nagashima, K, Matsuda, M

J Biol Chem 2000
10835426 CalDAG-GEFIII activation of Ras, R-ras, and Rap1

Yamashita, S, Mochizuki, N, Ohba, Y, Tobiume, M, Okada, Y, Sawa, H, Nagashima, K, Matsuda, M

J Biol Chem 2000
11221888 Phorbol esters modulate the Ras exchange factor RasGRP3

Lorenzo, PS, Kung, JW, Bottorff, DA, Garfield, SH, Stone, JC, Blumberg, PM

Cancer Res 2001
Participant Of
Catalyst Activity
Catalyst Activity
guanyl-nucleotide exchange factor activity of p-RASGRP1,3:DAG [plasma membrane]
Physical Entity
Orthologous Events
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