Reactome | p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP

p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP

Stable Identifier

R-HSA-1168636

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Activation of RAS by RasGRP1 and RasGRP3

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RasGRP1 (Roose et al. 2007) and RasGRP3 (Ohba et al. 2000, Yamashita et al. 2000, Rebhun et al. 2000, Lorenzo et al. 2001) catalyze the exchange of GDP for GTP bound by RAS.

Literature References

PubMed ID	Title	Journal	Year
17283063	Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes Roose, JP, Mollenauer, M, Ho, M, Kurosaki, T, Weiss, A	Mol Cell Biol	2007
10934204	Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction Rebhun, JF, Castro, AF, Quilliam, LA	J Biol Chem	2000
10777492	Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3 Ohba, Y, Mochizuki, N, Yamashita, S, Chan, AM, Schrader, JW, Hattori, S, Nagashima, K, Matsuda, M	J Biol Chem	2000
10835426	CalDAG-GEFIII activation of Ras, R-ras, and Rap1 Yamashita, S, Mochizuki, N, Ohba, Y, Tobiume, M, Okada, Y, Sawa, H, Nagashima, K, Matsuda, M	J Biol Chem	2000
11221888	Phorbol esters modulate the Ras exchange factor RasGRP3 Lorenzo, PS, Kung, JW, Bottorff, DA, Garfield, SH, Stone, JC, Blumberg, PM	Cancer Res	2001