NF-kappaB translocates from the cytosol to the nucleus

Stable Identifier
R-HSA-1168633
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NF-kappaB translocates from the cytosol to the nucleus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Nf-kappaB subunits contain nuclear localization sequences and, in the absence of IkB, are translocated to the nucleus (Bauerle and Baltimore 1988, Blank et al. 1991, Ghosh et al. 2008, Fagerlund et al. 2008). c-Rel binds to importins alpha5, alpha6, and alpha7; RelB binds to importins alpha5 and alpha6; p52 binds importin alpha3, alpha4, alpha5, and alpha6 (Fagerlund et al. 2008)

Literature References
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
NF-kappaB translocates from the cytosol to the nucleus (Bos taurus)
NF-kappaB translocates from the cytosol to the nucleus (Canis familiaris)
NF-kappaB translocates from the cytosol to the nucleus (Danio rerio)
NF-kappaB translocates from the cytosol to the nucleus (Drosophila melanogaster)
NF-kappaB translocates from the cytosol to the nucleus (Gallus gallus)
NF-kappaB translocates from the cytosol to the nucleus (Mus musculus)
NF-kappaB translocates from the cytosol to the nucleus (Rattus norvegicus)
NF-kappaB translocates from the cytosol to the nucleus (Sus scrofa)
NF-kappaB translocates from the cytosol to the nucleus (Xenopus tropicalis)
Authored
May, B  (2010-12-19)
Reviewed
Wienands, J  (2012-02-12)
Created
May, B  (2011-01-04)