NF-kappaB translocates from the cytosol to the nucleus

Stable Identifier
R-HSA-1168633
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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NF-kappaB translocates from the cytosol to the nucleus
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Nf-kappaB subunits contain nuclear localization sequences and, in the absence of IkB, are translocated to the nucleus (Bauerle and Baltimore 1988, Blank et al. 1991, Ghosh et al. 2008, Fagerlund et al. 2008). c-Rel binds to importins alpha5, alpha6, and alpha7; RelB binds to importins alpha5 and alpha6; p52 binds importin alpha3, alpha4, alpha5, and alpha6 (Fagerlund et al. 2008)

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Orthologous Events
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Authored
May, B  (2010-12-18)
Reviewed
Wienands, J  (2012-02-11)
Created
May, B  (2011-01-03)
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